[Analysis of Histologic Transformation and Prognosis for Follicular Lymphoma].

Autor: Zhao TJ; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China., Xu D; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China., Chai XF; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China., Chen YF; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China., Wang DM; Department of Infection, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China., Fu XR; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China., Li ZM; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China,E-mail: fcclizm@zzu.edu.cn.
Jazyk: čínština
Zdroj: Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2023 Auguest; Vol. 31 (4), pp. 1069-1076.
DOI: 10.19746/j.cnki.issn.1009-2137.2023.04.022
Abstrakt: Objective: To investigate the related factors of invasive transformation and prognosis for follicular lymphoma.
Methods: A total of 168 patients with follicular lymphoma at First Affiliated Hospital of Zhengzhou University from August 2015 to January 2021 were collected, and the significance of each index in histological transformation (HT) and prognosis were analyzed.
Results: Pathology grade3, Ki-67 index ≥40%, β 2 MG＞3 mg/L, LDH＞245 U/L, POD24 and non-invasion of bone marrow were associated with HT. Univariate analysis showed that the high risk of FLIPI-2, pathological grade 3, Ki-67≥40%, anemia, β 2 MG＞3 mg/L, LDH＞245 U/L and HT had significant adverse effects on PFS; β 2 MG＞3 mg/L, LDH＞245 U/L, POD24 and HT had significant adverse effects on OS. Cox multivariate analysis showed that the β 2 MG >3 mg/L and HT were independent risk factors of PFS, HT was independent risk factor of OS.
Conclusion: The pathological grade, Ki-67, β 2 MG, LDH, POD24 and bone marrow invasion of FL can predict the risk of HT. Meanwhile, β 2 MG >3 mg/L and HT are significantly related to poor prognosis of FL.
Databáze: MEDLINE
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