Transcriptomics age acceleration in prolonged treated HIV infection.

Autor: Mikaeloff F; The Systems Virology Lab, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden., Gelpi M; Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Escos A; The Systems Virology Lab, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden., Knudsen AD; Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Høgh J; Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Benfield T; Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark., de Magalhães JP; Institute of Inflammation and Ageing, University of Birmingham, Queen Elizabeth Hospital, Mindelsohn Way, Birmingham, UK., Nielsen SD; Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Neogi U; The Systems Virology Lab, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Jazyk: angličtina
Zdroj: Aging cell [Aging Cell] 2023 Oct; Vol. 22 (10), pp. e13951. Date of Electronic Publication: 2023 Aug 07.
DOI: 10.1111/acel.13951
Abstrakt: Biological aging in people with HIV (PWH) with prolonged successful antiretroviral therapy (ART) is convoluted and poorly defined. Here, we aimed to investigate the transcriptomics age estimator (TAE) in a cohort of 178 PWH on prolonged successful ART with immune reconstitution and viral suppression from the Copenhagen Comorbidity (COCOMO) cohort. We also used 143 clinical, demographical, and lifestyle factors to identify the confounders potentially responsible or associated with age acceleration. Among the PWH, 43% had an accelerated aging process (AAP), and 21% had decelerated aging process (DAP). DAP is linked with older age, European ancestry, and higher use of tenofovir disoproxil/alafenamide fumarate. A directionally class-based gene set enrichment analysis identified the upregulation of inflammatory pathways (e.g., cytokine and Retinoic acid-inducible gene I (RIG-I)-like receptor signaling pathways) and immune response like T-cell receptor signaling, antigen processing, and presentation in AAP and the downregulation of metabolic processes like oxidative phosphorylation, pyruvate metabolism.
(© 2023 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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