Cortical and subcortical mapping of the allostatic-interoceptive system in the human brain: replication and extension with 7 Tesla fMRI.

Autor:	Zhang J; Department of Psychology, Northeastern University, Boston, MA 02115., Chen D; Department of Psychology, Northeastern University, Boston, MA 02115., Srirangarajan T; Department of Psychology, Stanford University, Stanford, CA 94305., Theriault J; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02139., Kragel PA; Department of Psychology, Emory University, Atlanta, GA 30322., Hartley L; Department of Psychology, Northeastern University, Boston, MA 02115., Lee KM; Department of Psychology, Northeastern University, Boston, MA 02115., McVeigh K; Department of Psychology, Northeastern University, Boston, MA 02115., Wager TD; Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755., Wald LL; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02139., Satpute AB; Department of Psychology, Northeastern University, Boston, MA 02115., Quigley KS; Department of Psychology, Northeastern University, Boston, MA 02115., Whitfield-Gabrieli S; Department of Psychology, Northeastern University, Boston, MA 02115., Barrett LF; Department of Psychology, Northeastern University, Boston, MA 02115.; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02139.; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02139., Bianciardi M; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02139.; Division of Sleep Medicine, Harvard University, Boston, MA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2023 Jul 24. Date of Electronic Publication: 2023 Jul 24.
DOI:	10.1101/2023.07.20.548178
Abstrakt:	The brain continuously anticipates the energetic needs of the body and prepares to meet those needs before they arise, a process called allostasis. In support of allostasis, the brain continually models the internal state of the body, a process called interoception. Using published tract-tracing studies in non-human animals as a guide, we previously identified a large-scale system supporting allostasis and interoception in the human brain with functional magnetic resonance imaging (fMRI) at 3 Tesla. In the present study, we replicated and extended this system in humans using 7 Tesla fMRI ( N = 91 ), improving the precision of subgenual and pregenual anterior cingulate topography as well as brainstem nuclei mapping. We verified over 90% of the anatomical connections in the hypothesized allostatic-interoceptive system observed in non-human animal research. We also identified functional connectivity hubs verified in tract-tracing studies but not previously detected using 3 Tesla fMRI. Finally, we demonstrated that individuals with stronger fMRI connectivity between system hubs self-reported greater interoceptive awareness, building on construct validity evidence from our earlier paper. Taken together, these results strengthen evidence for the existence of a whole-brain system supporting interoception in the service of allostasis and we consider the implications for mental and physical health. Competing Interests: Competing interest statement: The authors declare no conflict of interest.
Databáze:	MEDLINE
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