Risk assessment and antibody responses to SARS-CoV-2 in healthcare workers.

Autor:	Bansal A; Department of Clinical Science, Influenza Centre, University of Bergen, Bergen, Norway., Trieu MC; Department of Clinical Science, Influenza Centre, University of Bergen, Bergen, Norway., Mohn KGI; Department of Clinical Science, Influenza Centre, University of Bergen, Bergen, Norway.; Department of Medicine, Haukeland University Hospital, Bergen, Norway., Madsen A; Department of Clinical Science, Influenza Centre, University of Bergen, Bergen, Norway., Olofsson JS; Department of Clinical Science, Influenza Centre, University of Bergen, Bergen, Norway., Sandnes HH; Department of Clinical Science, Influenza Centre, University of Bergen, Bergen, Norway., Sævik M; Department of Medicine, Haukeland University Hospital, Bergen, Norway., Søyland H; Department of Medicine, Haukeland University Hospital, Bergen, Norway., Hansen L; Department of Clinical Science, Influenza Centre, University of Bergen, Bergen, Norway., Onyango TB; Department of Clinical Science, Influenza Centre, University of Bergen, Bergen, Norway., Tøndel C; Department of Clinical Science, Influenza Centre, University of Bergen, Bergen, Norway.; Department of Paediatrics, Haukeland University Hospital, Bergen, Norway., Brokstad KA; Department of Clinical Science, Influenza Centre, University of Bergen, Bergen, Norway.; Department of Safety, Chemistry and Biomedical Laboratory Sciences, Western Norway University of Applied Sciences, Bergen, Norway., Syre H; Department of Medical Microbiology, Stavanger University Hospital, Stavanger, Norway., Riis ÅG; Department of Medicine, Stavanger University Hospital, Stavanger, Norway., Langeland N; Department of Medicine, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway., Cox RJ; Department of Clinical Science, Influenza Centre, University of Bergen, Bergen, Norway.; Department of Microbiology, Haukeland University Hospital, Bergen, Norway.
Jazyk:	angličtina
Zdroj:	Frontiers in public health [Front Public Health] 2023 Jul 21; Vol. 11, pp. 1164326. Date of Electronic Publication: 2023 Jul 21 (Print Publication: 2023).
DOI:	10.3389/fpubh.2023.1164326
Abstrakt:	Background: Preventing infection in healthcare workers (HCWs) is crucial for protecting healthcare systems during the COVID-19 pandemic. Here, we investigated the seroepidemiology of SARS-CoV-2 in HCWs in Norway with low-transmission settings. Methods: From March 2020, we recruited HCWs at four medical centres. We determined infection by SARS-CoV-2 RT-PCR and serological testing and evaluated the association between infection and exposure variables, comparing our findings with global data in a meta-analysis. Anti-spike IgG antibodies were measured after infection and/or vaccination in a longitudinal cohort until June 2021. Results: We identified a prevalence of 10.5% (95% confidence interval, CI: 8.8-12.3) in 2020 and an incidence rate of 15.0 cases per 100 person-years (95% CI: 12.5-17.8) among 1,214 HCWs with 848 person-years of follow-up time. Following infection, HCWs ( n = 63) mounted durable anti-spike IgG antibodies with a half-life of 4.3 months since their seropositivity. HCWs infected with SARS-CoV-2 in 2020 ( n = 46) had higher anti-spike IgG titres than naive HCWs ( n = 186) throughout the 5 months after vaccination with BNT162b2 and/or ChAdOx1-S COVID-19 vaccines in 2021. In a meta-analysis including 20 studies, the odds ratio (OR) for SARS-CoV-2 seropositivity was significantly higher with household contact (OR 12.6; 95% CI: 4.5-35.1) and occupational exposure (OR 2.2; 95% CI: 1.4-3.2). Conclusion: We found high and modest risks of SARS-CoV-2 infection with household and occupational exposure, respectively, in HCWs, suggesting the need to strengthen infection prevention strategies within households and medical centres. Infection generated long-lasting antibodies in most HCWs; therefore, we support delaying COVID-19 vaccination in primed HCWs, prioritising the non-infected high-risk HCWs amid vaccine shortage. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Bansal, Trieu, Mohn, Madsen, Olofsson, Sandnes, Sævik, Søyland, Hansen, Onyango, Tøndel, Brokstad, Bergen COVID-19 research group, Syre, Riis, Langeland and Cox.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu