Surgical androgen deprivation therapy in advanced prostate cancer in patients of African descent: comparison of biochemical efficacy of bilateral total and subcapsular orchidectomy.
| Autor: | Arogundade AK; Federal Teaching Hospital, Urology Unit, Department of Surgery., Popoola AA; University of Ilorin Teaching Hospital, Urology Division, Department of Surgery., Ajape AA; University of Ilorin Teaching Hospital, Urology Division, Department of Surgery., Abiola OO; Bowen University Teaching Hospital, Urology Unit, Department of Surgery., Biliaminu SA; University of Ilorin Teaching Hospital, Chemical Pathology and Immunology. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | African health sciences [Afr Health Sci] 2023 Mar; Vol. 23 (1), pp. 483-491. |
| DOI: | 10.4314/ahs.v23i1.50 |
| Abstrakt: | Background: Surgical androgen deprivation therapy (ADT) to treat advanced prostate cancer can be achieved either by bilateral total orchidectomy (BTO) or bilateral subcapsular orchidectomy (BSCO). However, biochemical and clinical equivalence between BTO and BSCO among native Africans is undocumented. Objective: To compare the biochemical response (testosterone and prostate specific antigen) in patients who had BTO and BSCO for advanced prostate cancer. Methods: A randomized single- blind study of 64 consenting patients that underwent either BTO or BSCO. Pre- and post-operative PSA and testosterone assays were done serially at intervals and compared between each treatment group. Results: Each treatment group were similar with no statistically significant difference in terms of age (p= 0.449) or degree of tumor differentiation (p =0.714). Neither median testosterone (p= 0.515) nor the mean pre-operative PSA differ between the two groups (p = 0.482). Also, similar trends were noticed post operatively except at the 2 nd month when a statistically significant difference was recorded (p = 0.003). Conclusion: The two techniques of orchidectomy were effective in accomplishing androgen deprivation. They produced similar biochemical (testosterone and PSA) response. (© 2023 Arogundade AK et al.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|