Low-frequency electrokinetics in a periodic pillar array for particle separation.

Autor: Calero V; Depto. Electrónica y Electromagnetismo, Facultad de Física, Universidad de Sevilla, Avda. Reina Mercedes s/n, 41012, Sevilla, Spain; International Iberian Nanotechnology Laboratory (INL), Braga 4715-330, Portugal., Fernández-Mateo R; School of Electronics and Computer Science, University of Southampton, Southampton SO17 1BJ, United Kingdom., Morgan H; School of Electronics and Computer Science, University of Southampton, Southampton SO17 1BJ, United Kingdom., García-Sánchez P; Depto. Electrónica y Electromagnetismo, Facultad de Física, Universidad de Sevilla, Avda. Reina Mercedes s/n, 41012, Sevilla, Spain. Electronic address: pablogarcia@us.es., Ramos A; Depto. Electrónica y Electromagnetismo, Facultad de Física, Universidad de Sevilla, Avda. Reina Mercedes s/n, 41012, Sevilla, Spain.
Jazyk: angličtina
Zdroj: Journal of chromatography. A [J Chromatogr A] 2023 Sep 13; Vol. 1706, pp. 464240. Date of Electronic Publication: 2023 Jul 28.
DOI: 10.1016/j.chroma.2023.464240
Abstrakt: Deterministic Lateral Displacement (DLD) exploits periodic arrays of pillars inside microfluidic channels for high-precision sorting of micro- and nano-particles. Previously we demonstrated how DLD separation can be significantly improved by the addition of AC electrokinetic forces, increasing the tunability of the technique and expanding the range of applications. At high frequencies of the electric field (>1 kHz) the behaviour of such systems is dominated by Dielectrophoresis (DEP), whereas at low frequencies the particle behaviour is much richer and more complex. In this article, we present a detailed numerical analysis of the mechanisms governing particle motion in a DLD micropillar array in the presence of a low-frequency AC electric field. We show how a combination of Electrophoresis (EP) and Concentration-Polarisation Electroosmosis (CPEO) driven wall-particle repulsion account for the observed experimental behaviour of particles, and demonstrate how this complete model can predict conditions that lead to electrically induced deviation of particles much smaller than the critical size of the DLD array.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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