Astrocytes adjust the dynamic range of cortical network activity to control modality-specific sensory information processing.

Autor:	Miguel-Quesada C; Neuronal Circuits and Behaviour Group, Hospital Nacional de Parapléjicos, Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), 45071 Toledo, Spain; Experimental Neurophysiology Group, Hospital Nacional de Parapléjicos, Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), 45071 Toledo, Spain., Zaforas M; Experimental Neurophysiology Group, Hospital Nacional de Parapléjicos, Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), 45071 Toledo, Spain., Herrera-Pérez S; Experimental Neurophysiology Group, Hospital Nacional de Parapléjicos, Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), 45071 Toledo, Spain., Lines J; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA., Fernández-López E; Experimental Neurophysiology Group, Hospital Nacional de Parapléjicos, Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), 45071 Toledo, Spain., Alonso-Calviño E; Experimental Neurophysiology Group, Hospital Nacional de Parapléjicos, Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), 45071 Toledo, Spain., Ardaya M; Donostia International Physics Center (DIPC), 20018 San Sebastian, Spain; Achucarro Basque Center for Neuroscience, 48940 Leioa, Spain., Soria FN; Achucarro Basque Center for Neuroscience, 48940 Leioa, Spain; Ikerbasque, Basque Foundation for Science, 48009 Bilbao, Spain; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Araque A; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA., Aguilar J; Experimental Neurophysiology Group, Hospital Nacional de Parapléjicos, Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), 45071 Toledo, Spain. Electronic address: jdaguilar@sescam.jccm.es., Rosa JM; Neuronal Circuits and Behaviour Group, Hospital Nacional de Parapléjicos, Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), 45071 Toledo, Spain. Electronic address: jmartinsd@sescam.jccm.es.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2023 Aug 29; Vol. 42 (8), pp. 112950. Date of Electronic Publication: 2023 Aug 05.
DOI:	10.1016/j.celrep.2023.112950
Abstrakt:	Cortical neuron-astrocyte communication in response to peripheral sensory stimulation occurs in a topographic-, frequency-, and intensity-dependent manner. However, the contribution of this functional interaction to the processing of sensory inputs and consequent behavior remains unclear. We investigate the role of astrocytes in sensory information processing at circuit and behavioral levels by monitoring and manipulating astrocytic activity in vivo. We show that astrocytes control the dynamic range of the cortical network activity, optimizing its responsiveness to incoming sensory inputs. The astrocytic modulation of sensory processing contributes to setting the detection threshold for tactile and thermal behavior responses. The mechanism of such astrocytic control is mediated through modulation of inhibitory transmission to adjust the gain and sensitivity of responding networks. These results uncover a role for astrocytes in maintaining the cortical network activity in an optimal range to control behavior associated with specific sensory modalities. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu