Natural killer cell-derived exosomes for cancer immunotherapy: innovative therapeutics art.

Autor: Hatami Z; Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran., Hashemi ZS; ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran. z.hashemi@acecr.ac.ir., Eftekhary M; Department of Medical Biotechnology, Faculty of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran., Amiri A; Department of Biotechnology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran., Karpisheh V; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Nasrollahi K; Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran., Jafari R; Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran. rezajaafary1983@gmail.com.
Jazyk: angličtina
Zdroj: Cancer cell international [Cancer Cell Int] 2023 Aug 05; Vol. 23 (1), pp. 157. Date of Electronic Publication: 2023 Aug 05.
DOI: 10.1186/s12935-023-02996-6
Abstrakt: Chimeric antigen receptor natural killer cells (CAR-NK) promote off-the-shelf cellular therapy for solid tumors and malignancy.However,, the development of CAR-NK is due to their immune surveillance uncertainty and cytotoxicity challenge was restricted. Natural killer cell-derived exosome (NK-Exo) combine crucial targeted cellular therapies of NK cell therapies with unique non-toxic Exo as a self-origin shuttle against cancer immunotherapy. This review study covers cytokines, adoptive (autologous and allogenic) NK immunotherapy, stimulatory and regulatory functions, and cell-free derivatives from NK cells. The future path of NK-Exo cytotoxicity and anti-tumor activity with considering non-caspase-independent/dependent apoptosis and Fas/FasL pathway in cancer immunotherapy. Finally, the significance and implication of NK-Exo therapeutics through combination therapy and the development of emerging approaches for the purification and delivery NK-Exo to severe immune and tumor cells and tissues were discussed in detail.
(© 2023. BioMed Central Ltd., part of Springer Nature.)
Databáze: MEDLINE
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