Multi-omics approaches in psychoneuroimmunology and health research: Conceptual considerations and methodological recommendations.

Autor: Mengelkoch S; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA. Electronic address: smengelkoch@mednet.ucla.edu., Miryam Schüssler-Fiorenza Rose S; Department of Genetics, Stanford University, Stanford, CA, USA., Lautman Z; Department of Genetics, Stanford University, Stanford, CA, USA., Alley JC; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA., Roos LG; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA., Ehlert B; Department of Genetics, Stanford University, Stanford, CA, USA., Moriarity DP; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA., Lancaster S; Department of Genetics, Stanford University, Stanford, CA, USA., Snyder MP; Department of Genetics, Stanford University, Stanford, CA, USA., Slavich GM; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA. Electronic address: gslavich@mednet.ucla.edu.
Jazyk: angličtina
Zdroj: Brain, behavior, and immunity [Brain Behav Immun] 2023 Nov; Vol. 114, pp. 475-487. Date of Electronic Publication: 2023 Aug 04.
DOI: 10.1016/j.bbi.2023.07.022
Abstrakt: The field of psychoneuroimmunology (PNI) has grown substantially in both relevance and prominence over the past 40 years. Notwithstanding its impressive trajectory, a majority of PNI studies are still based on a relatively small number of analytes. To advance this work, we suggest that PNI, and health research in general, can benefit greatly from adopting a multi-omics approach, which involves integrating data across multiple biological levels (e.g., the genome, proteome, transcriptome, metabolome, lipidome, and microbiome/metagenome) to more comprehensively profile biological functions and relate these profiles to clinical and behavioral outcomes. To assist investigators in this endeavor, we provide an overview of multi-omics research, highlight recent landmark multi-omics studies investigating human health and disease risk, and discuss how multi-omics can be applied to better elucidate links between psychological, nervous system, and immune system activity. In doing so, we describe how to design high-quality multi-omics studies, decide which biological samples (e.g., blood, stool, urine, saliva, solid tissue) are most relevant, incorporate behavioral and wearable sensing data into multi-omics research, and understand key data quality, integration, analysis, and interpretation issues. PNI researchers are addressing some of the most interesting and important questions at the intersection of psychology, neuroscience, and immunology. Applying a multi-omics approach to this work will greatly expand the horizon of what is possible in PNI and has the potential to revolutionize our understanding of mind-body medicine.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article.
(Copyright © 2023. Published by Elsevier Inc.)
Databáze: MEDLINE
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