Clozapine safety monitoring and related research in psychiatry and neurology in South America: A scoping review.

Autor: Baptista T; Department of Physiology, Los Andes University Medical School, Mérida, Venezuela; Medical School, Anáhuac University, Querétaro, Mexico; Neuroorigen, Querétaro, Mexico. Electronic address: trinobaptista@gmail.com., Serrano A; SAMEIN, Salud Mental Integral SAS, Medellin, Colombia. Electronic address: aserrano.Ve@gmail.com., Presti APL; Centro de Salud Mental y Comunitario Dr Germán Greve Schlegel, Santiago, Chile. Electronic address: aperezlopresti@gmail.com., Fernandez-Arana A; Instituto de Neurociencias Aplicadas, Lima, Peru. Electronic address: a.fernandez@neurocienciasaplicadas.com., Elkis H; Department and Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil. Electronic address: helkis@usp.br., Motuca M; Department of Psychiatry, School of Medicine at Universidad Nacional de Cuyo, Mendoza, Argentina; Instituto Vilapriño, Centro de Estudios, Asistencia e Investigación en Neurociencias, Mendoza, Argentina. Electronic address: memotuca@gmail.com., Olmos I; Clinical Pharmacology Unit and Pharmacy Department, Vilardebó Hospital, Administración de Servicios de Salud, Montevideo, Uruguay; Clinical Pharmacology Unit and Outpatient Clinic, Vilardebó Hospital, Administración de Servicios de Salud, Montevideo, Uruguay. Electronic address: ismael.olmos@asse.com.uy., Schoretsanitis G; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zürich, Zürich, Switzerland; The Zucker Hillside Hospital, Psychiatry Research, Northwell Health, Glen Oaks, NY, USA; Department of Psychiatry, Zucker School of Medicine at Northwell/Hofstra, Hempstead, NY, USA. Electronic address: george.schor@gmail.com.
Jazyk: angličtina
Zdroj: Schizophrenia research [Schizophr Res] 2024 Jun; Vol. 268, pp. 29-33. Date of Electronic Publication: 2023 Aug 03.
DOI: 10.1016/j.schres.2023.07.029
Abstrakt: The quality and quantity of clozapine safety monitoring considerably differs among South American countries and mainly focus on hematological surveillance. Few studies have been conducted on other clozapine-related adverse effects (ADRs) and mainly refer to case reports and literature reviews. We retrieved thirty-nine publications on clozapine related ADRs others than neutropenia. Studies in Brazil and Venezuela accounted for 67 % of all the publications, and 8 out of 12 countries published 2 or less manuscripts. Only Chile offers serum clozapine level measurement in public institutions. Given the recently recognized role of ethnicity, gender, smoking, obesity drug interactions in optimal clozapine administration, modernization of clozapine clinical use and research in psychiatry and neurology most be broadcasted and stimulated in South American countries.
Competing Interests: Declaration of competing interest The authors report no competing conflicts of interest concerning the manuscript.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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