Circulating ovarian hormones interact with protein interacting with C kinase (PICK1) within the medial prefrontal cortex to influence cocaine seeking in female mice.

Autor: Birmingham EA; Department of Psychology & Neuroscience, Temple University, United States of America., Wickens MM; Department of Psychology & Neuroscience, Temple University, United States of America., Kirkland JM; Department of Psychology & Neuroscience, Temple University, United States of America., Knouse MC; Department of Psychology & Neuroscience, Temple University, United States of America., McGrath AG; Department of Psychology & Neuroscience, Temple University, United States of America., Briand LA; Department of Psychology & Neuroscience, Temple University, United States of America; Neuroscience Program, Temple University, United States of America. Electronic address: lbriand@temple.edu.
Jazyk: angličtina
Zdroj: Hormones and behavior [Horm Behav] 2023 Sep; Vol. 155, pp. 105408. Date of Electronic Publication: 2023 Aug 02.
DOI: 10.1016/j.yhbeh.2023.105408
Abstrakt: Protein interacting with C kinase 1 (PICK1) is an AMPA receptor binding protein that works in conjunction with glutamate receptor interacting protein (GRIP) to balance the number of GluA2-containing AMPARs in the synapse. In male mice, disrupting PICK1 in the medial prefrontal cortex (mPFC) leads to a decrease in cue-induced cocaine seeking and disrupting GRIP in the mPFC has the opposing effect, consistent with other evidence that removal of GluA2-containing AMPARs potentiates reinstatement. However, PICK1 does not seem to play the same role in female mice, as knockdown of either PICK1 or GRIP in the mPFC leads to similar increases in cue-induced cocaine seeking. These previous findings indicate that the role of PICK1 in the prefrontal cortex is sex specific. The goal of the current study was to examine whether ovarian hormones contribute to the effect of prefrontal PICK1 knockdown on reinstatement of cocaine seeking. While we replicated the increased cue-induced cocaine seeking in prefrontal PICK1 knockdown sham mice, we did not see any difference between the GFP control mice and PICK1 knockdowns following ovariectomy. However, this effect was driven primarily by an increase in cocaine seeking in ovariectomized GFP control mice while there was no effect ovariectomy in PICK1 knockdown mice. Taken together, these findings suggest that circulating ovarian hormones interact with the effects of PICK1 on cue-induced reinstatement.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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