Uncovering the endemic circulation of rabies in Cambodia.

Autor: Layan M; Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, Université Paris Cité, UMR2000, CNRS, Paris, France.; Collège Doctoral, Sorbonne Université, Paris, France., Dacheux L; Lyssavirus Epidemiology and Neuropathology Unit, Institut Pasteur, Université Paris Cité, Paris, France.; WHO Collaborating Centre for Reference and Research on Rabies, Institut Pasteur, Université Paris Cité, Paris, France., Lemey P; Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory for Clinical and Epidemiological Virology, KU Leuven, University of Leuven, Leuven, Belgium., Brunker K; Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK., Ma L; Biomics, Center for Technological Resources and Research (C2RT), Institut Pasteur, Université Paris Cité, Paris, France., Troupin C; Virology Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia., Dussart P; Virology Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia., Chevalier V; CIRAD, UMR ASTRE, Montpellier, France.; ASTRE, Univ. Montpellier CIRAD, INRAE, Montpellier, France.; Epidemiology and Clinical Research, Institut Pasteur de Madagascar, Antananarivo, Madagascar., Wood JLN; Department of Veterinary Medicine, University of Cambridge, Cambridge, UK., Ly S; Epidemiology and Public Health, Institut Pasteur du Cambodge, Phnom Penh, Cambodia., Duong V; Virology Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia., Bourhy H; Lyssavirus Epidemiology and Neuropathology Unit, Institut Pasteur, Université Paris Cité, Paris, France.; WHO Collaborating Centre for Reference and Research on Rabies, Institut Pasteur, Université Paris Cité, Paris, France., Dellicour S; Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory for Clinical and Epidemiological Virology, KU Leuven, University of Leuven, Leuven, Belgium.; Spatial Epidemiology Lab (SpELL), Université Libre de Bruxelles, Bruxelles, Belgium.
Jazyk: angličtina
Zdroj: Molecular ecology [Mol Ecol] 2023 Sep; Vol. 32 (18), pp. 5140-5155. Date of Electronic Publication: 2023 Aug 04.
DOI: 10.1111/mec.17087
Abstrakt: In epidemiology, endemicity characterizes sustained pathogen circulation in a geographical area, which involves a circulation that is not being maintained by external introductions. Because it could potentially shape the design of public health interventions, there is an interest in fully uncovering the endemic pattern of a disease. Here, we use a phylogeographic approach to investigate the endemic signature of rabies virus (RABV) circulation in Cambodia. Cambodia is located in one of the most affected regions by rabies in the world, but RABV circulation between and within Southeast Asian countries remains understudied. Our analyses are based on a new comprehensive data set of 199 RABV genomes collected between 2014 and 2017 as well as previously published Southeast Asian RABV sequences. We show that most Cambodian sequences belong to a distinct clade that has been circulating almost exclusively in Cambodia. Our results thus point towards rabies circulation in Cambodia that does not rely on external introductions. We further characterize within-Cambodia RABV circulation by estimating lineage dispersal metrics that appear to be similar to other settings, and by performing landscape phylogeographic analyses to investigate environmental factors impacting the dispersal dynamic of viral lineages. The latter analyses do not lead to the identification of environmental variables that would be associated with the heterogeneity of viral lineage dispersal velocities, which calls for a better understanding of local dog ecology and further investigations of the potential drivers of RABV spread in the region. Overall, our study illustrates how phylogeographic investigations can be performed to assess and characterize viral endemicity in a context of relatively limited data.
(© 2023 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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