Mesobiliverdin IXα-enriched microalgae feed additive eliminates reliance on antibiotic tylosin to promote intestinal health of weaning piglets.

Autor: Liao TS; Department of Animal Science and Technology, National Taiwan University, Taipei City, Taiwan., Chen CY; Department of Animal Science and Technology, National Taiwan University, Taipei City, Taiwan., Lin CS; Animal Technology Research Center, Agricultural Technology Research Institute, Miaoli County, Taiwan., Chang CT; Department of Chemistry and Biochemistry, Utah State University, Logan, Utah, USA., Takemoto JY; Department of Biology, Utah State University, Logan, Utah, USA., Lin YY; Department of Animal Science and Technology, National Taiwan University, Taipei City, Taiwan.
Jazyk: angličtina
Zdroj: Journal of animal physiology and animal nutrition [J Anim Physiol Anim Nutr (Berl)] 2023 Nov; Vol. 107 (6), pp. 1368-1375. Date of Electronic Publication: 2023 Aug 04.
DOI: 10.1111/jpn.13867
Abstrakt: Weaning is a critical period in raising pigs. Novel animal feed additives that promote gut health and regulate immune function of piglets without antibiotics are needed. In this study, we aimed to test the ability of mesobiliverdin IXα-enriched microalgae (MBV IXα-enriched microalgae) to eliminate reliance on antibiotics to promote intestinal health in piglets. Eighty 28-day-old weaned piglets were randomly allocated to four groups each with four replicate pens and five piglets per pen. The dietary treatments were a basal diet as control (NC), basal diet plus 0.05% tylosin (PC), basal diet plus 0.1% or 0.5% MBV IXα-enriched microalgae as low (MBV-SP1) or high (MBV-SP2) dose respectively. All treated animals showed no significant differences in live weight, average daily gain and feed efficiency compared to control animals. Histological examination showed that MBV-SP1 and particularly MBV-SP2 increased the ratio of villus height to crypt depth in the jejunum and ileum compared to NC (p < 0.05). Similarly, tylosin treatment also increased villi lengths and the ratio of villus height to crypt depth in the jejunum and ileum compared to the NC (p < 0.05). MBV-SP1 and particularly MBV-SP2 reduced the levels of inflammatory cytokines interleukin-6 and tumour necrosis factor-alpha in the small intestine. MBV-SP2 and tylosin similarly reduced the lipid peroxidation marker (TBARS value) in the duodenum and ileum. In conclusion, feed supplementation with MBV IXα-enriched microalgae improved gut health by villus height and production of immunomodulators that correlated with down-regulated secretion of inflammatory cytokines.
(© 2023 Wiley-VCH GmbH. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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