Antimicrobial and in silico studies of the triterpenoids of Dichapetalum albidum.

Autor: Chama MA; Department of Chemistry, SPMS, CBAS, University of Ghana, Ghana., Dziwornu GA; Department of Chemistry, SPMS, CBAS, University of Ghana, Ghana., Popli E; Yusuf Hamied Department of Chemistry, University of Cambridge, United Kingdom., Mas-Claret E; Royal Botanic Gardens, Kew, Richmond, TW9 3AQ, United Kingdom., Egyir B; Department of Bacteriology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Ghana., Ayine-Tora DM; Department of Chemistry, SPMS, CBAS, University of Ghana, Ghana., Owusu KB; Department of Parasitology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Ghana., Reid DG; Yusuf Hamied Department of Chemistry, University of Cambridge, United Kingdom., Osei-Safo D; Department of Chemistry, SPMS, CBAS, University of Ghana, Ghana., Duer M; Yusuf Hamied Department of Chemistry, University of Cambridge, United Kingdom., Mulholland D; Department of Chemistry, University of Surrey, Guildford, United Kingdom., Bender A; Yusuf Hamied Department of Chemistry, University of Cambridge, United Kingdom.
Jazyk: angličtina
Zdroj: Heliyon [Heliyon] 2023 Jul 14; Vol. 9 (7), pp. e18299. Date of Electronic Publication: 2023 Jul 14 (Print Publication: 2023).
DOI: 10.1016/j.heliyon.2023.e18299
Abstrakt: Here we report a new polyhydroxylated triterpene, 2β,6β,21α-trihydroxyfriedelan-3-one ( 4 ) isolated from the root and stem bark of Dichapetalum albidum A. Chev (Dichapetalaceae), along with six known triterpenoids ( 1 - 3 , 5 , 6 , 8 ), sitosterol-3β- O -D-glucopyranoside ( 9 ), a dipeptide ( 7 ), and a tyramine derivative of coumaric acid ( 10 ). Friedelan-3-one ( 2 ) showed an antimicrobial activity (IC 50 ) of 11.40 μg/mL against Bacillus cereus , while friedelan-3α-ol ( 1 ) gave an IC 50 of 13.07 μg/mL against Staphylococcus aureus with ampicillin reference standard of 19.52 μg/mL and 0.30 μg/mL respectively. 3β-Acetyl tormentic acid ( 5 ) showed an IC 50 of 12.50 μg/mL against Trypanosoma brucei brucei and sitosterol-3β- O -d-glucopyranoside ( 9 ) showed an IC 50 of 5.06 μg/mL against Leishmania donovani with respective reference standards of IC 50 5.02 μg/mL for suramin and IC 50 0.27 μg/mL for amphotericin B. Molecular docking of the isolated compounds on the enzyme glucose-6-phosphate dehydrogenase (G6PDH) suggested 3β-acetyl tormentic acid ( 5 ) and sitosterol-3β- O -D-glucopyranoside ( 9) as plausible inhibitors of the enzyme in accordance with the experimental biological results observed.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2023 Published by Elsevier Ltd.)
Databáze: MEDLINE
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