Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2014 to 2018 in Japan: A large-scale multicenter retrospective study.

Autor: Fujii H; Department of Hepatology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan., Suzuki Y; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan., Sawada K; Division of Metabolism and Biosystemic Science, Gastroenterology, and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan., Tatsuta M; Department of Gastroenterology, KKR Takamatsu Hospital, Takamatsu, Kagawa, Japan., Maeshiro T; First Department of Internal Medicine, University of the Ryukyus Hospital, Okinawa, Japan., Tobita H; Department of Hepatology, Shimane University Hospital, Izumo, Shimane, Japan., Tsutsumi T; Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan., Akahane T; Department of Gastroenterology, Nara Medical University, Kashihara, Nara, Japan., Hasebe C; Department of Gastroenterology, Japanese Red Cross Asahikawa Hospital, Asahikawa, Hokkaido, Japan., Kawanaka M; Department of General Internal Medicine 2, Kawasaki Medical Center, Kawasaki Medical School, Kita, Okayama, Japan., Kessoku T; Kanagawa Dental University Yokohama Clinic, Yokohama, Japan.; Department of Palliative Medicine and Gastroenterology, International University Health and Welfare Narita Hospital, Chiba, Japan.; Division of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Eguchi Y; Loco Medical General Institute, Saga, Japan., Syokita H; Department of Gastroenterology, Northern OKINAWA Medical Center, Nago, Okinawa, Japan., Nakajima A; Division of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Kamada T; Department of Health Care Medicine, Kawasaki Medical School, Kita, Okayama, Japan., Yoshiji H; Department of Gastroenterology, Nara Medical University, Kashihara, Nara, Japan., Kawaguchi T; Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan., Sakugawa H; Department of Gastroenterology, Heartlife Hospital, Okinawa, Japan., Morishita A; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, Japan., Masaki T; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, Japan., Ohmura T; Department of Health Care, Asahikawa-Kosei General Hospital, Asahikawa, Hokkaido, Japan., Watanabe T; Department of Premier Preventive Medicine, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan., Kawada N; Department of Hepatology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan., Yoda Y; JA Yamanashi Koseiren Health Care Center, Yamanashi, Japan., Enomoto N; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan., Ono M; Division of Innovative Medicine for Hepatobiliary and Pancreatology, Faculty of Medicine, Kagawa University, Kagawa, Japan., Fuyama K; Data Science Center, Promotion Unit, Institute of Health Science Innovation for Medical Care, Hokkaido University Hospital, Sapporo, Japan., Okada K; Data Science Center, Promotion Unit, Institute of Health Science Innovation for Medical Care, Hokkaido University Hospital, Sapporo, Japan., Nishimoto N; Data Science Center, Promotion Unit, Institute of Health Science Innovation for Medical Care, Hokkaido University Hospital, Sapporo, Japan., Ito YM; Data Science Center, Promotion Unit, Institute of Health Science Innovation for Medical Care, Hokkaido University Hospital, Sapporo, Japan., Kamada Y; Department of Advanced Metabolic Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan., Takahashi H; Liver Center, Saga University Hospital, Saga, Japan., Sumida Y; Division of Hepatology and Pancreatology, Department of Internal Medicine, Aichi Medical University, Aichi, Japan.
Jazyk: angličtina
Zdroj: Hepatology research : the official journal of the Japan Society of Hepatology [Hepatol Res] 2023 Nov; Vol. 53 (11), pp. 1059-1072. Date of Electronic Publication: 2023 Aug 28.
DOI: 10.1111/hepr.13947
Abstrakt: Aim: The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. The aim of this study was to determine the recent prevalence and clinical characteristics of NAFLD in Japan.
Methods: This study initially included 410 061 retrospectively enrolled adults from the medical health checkup registry for metabolic syndrome, chronic kidney disease, and fatty liver in Japan (MIRACLE-J; UMIN-CTR no. UMIN000049419), who were evaluated between 2014 and 2018 at 13 health centers in Japan. Individuals consuming >20 g of alcohol/day or with chronic liver disease were excluded. Fatty liver was diagnosed by ultrasonography. The probability of NAFLD with advanced fibrosis was estimated based on the fibrosis-4 index and NAFLD fibrosis score.
Results: A total of 71 254 participants were included in the final analysis. The overall prevalence of NAFLD was 25.8%. There was a significant, twofold difference in NAFLD prevalence between men (37.4%) and women (18.1%). Nonalcoholic fatty liver disease prevalence increased linearly with body mass index, triglycerides, and low-density lipoprotein cholesterol regardless of threshold values, even in the absence of obesity. Among patients with NAFLD, 14% had diabetes mellitus, 31% had hypertension, and 48% had dyslipidemia. The estimated prevalence of NAFLD with advanced fibrosis was 1.7% and 1.0% according to the fibrosis-4 index and NAFLD fibrosis score, respectively.
Conclusions: The prevalence of NAFLD was approximately one-quarter of the general population in Japan. There was a linear relationship between NAFLD prevalence and various metabolic parameters, even in nonobese participants. The prevalence of NAFLD with advanced fibrosis was estimated to be 1%-2%.
(© 2023 The Japan Society of Hepatology.)
Databáze: MEDLINE
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