Preoperative prediction of the lymphovascular tumor thrombus of colorectal cancer with the iodine concentrations from dual-energy spectral CT.

Autor: Yuan X; Department of Radiology, The Affiliated Hospital of Southwest Medical University, No.25 taiping street, 64600, Luzhou, China., Quan X; Department of Radiology, The Affiliated Hospital of Southwest Medical University, No.25 taiping street, 64600, Luzhou, China., Che XL; Department of Radiology, The Affiliated Hospital of Southwest Medical University, No.25 taiping street, 64600, Luzhou, China., Xu LL; Department of Radiology, The Affiliated Hospital of Southwest Medical University, No.25 taiping street, 64600, Luzhou, China., Yang CM; Department of Radiology, The Affiliated Hospital of Southwest Medical University, No.25 taiping street, 64600, Luzhou, China., Zhang XD; Philips Healthcare, 610041, Chengdu, Sichuan, China., Shu J; Department of Radiology, The Affiliated Hospital of Southwest Medical University, No.25 taiping street, 64600, Luzhou, China. shujiannc@163.com.
Jazyk: angličtina
Zdroj: BMC medical imaging [BMC Med Imaging] 2023 Aug 03; Vol. 23 (1), pp. 103. Date of Electronic Publication: 2023 Aug 03.
DOI: 10.1186/s12880-023-01060-z
Abstrakt: Background: The aim of this study was to explore application value of iodine concentration from dual-energy spectral computed tomography (DESCT) in preoperative prediction of lymphovascular tumor thrombus in patients with colorectal cancer (CRC).
Methods: We finally retrospectively analyzed 50 patients with CRC who underwent abdominal DESCT before receiving any preoperative treatment and underwent surgery to obtain pathological specimens which were stained with hematoxylin-eosin (HE) staining. According to the presence of cancer cell nests in blood vessels and lymphatic vessels, the subjects were divided into the positive group and negative group of lymphovascular tumor thrombus. Two radiologists independently measured the normalized iodine concentration (NIC) values, effective atomic number (Zeff) and CT values of virtual monochromatic images (VMIs) at 40-90 keV of the primary tumors in the arterial phase (AP) and venous phase (VP). Used SPSS 17.0 to calculate the receiver operating characteristic (ROC) curve to evaluate diagnostic value.
Results: The patients were divided into lymphovascular tumor thrombus positive group(n = 16) and negative group(n = 34). The values of NIC-AP and NIC-VP in the positive group were 0.17 ± 0.09, 0.51 ± 0.13, respectively. And those in the negative group were 0.15 ± 0.06, 0.43 ± 0.12, respectively. There was significant difference in NIC-VP value between the two groups (p = 0.039), but there was no significant difference in NIC-AP value (p = 0.423). The optimal threshold value of NIC-VP value for diagnosis of lymphovascular tumor thrombus was 0.364. The sensitivity was 68.8% and the specificity was 67.6%.
Conclusions: The NIC-VP value of DESCT can be used to predict the presence or absence of the lymphovascular tumor thrombus in CRC patients before operation, which is helpful to select the best treatment scheme and evaluate its prognosis.
(© 2023. BioMed Central Ltd., part of Springer Nature.)
Databáze: MEDLINE
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