Donor-recipient specificity and age-dependency in fecal microbiota therapy and probiotic resolution of gastrointestinal symptoms.

Autor: Wu Q; Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, Houston, TX, USA., Boonma P; Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, Houston, TX, USA.; Faculty of Medicine, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand., Badu S; Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, Houston, TX, USA., Yalcinkaya N; Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, Houston, TX, USA., So SY; Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, Houston, TX, USA., Garey KW; Department of Pharmacy Practice and Translational Research, College of Pharmacy, University of Houston, Houston, TX, USA., Williams K; Department of Pediatrics, Ohio State University & Nationwide Children's Hospital, Columbus, OH, USA., Arnold LE; Department of Psychiatry and Behavioral Health, Ohio State University, Columbus, OH, USA., Shulman RJ; Department of Pediatrics, Baylor College of Medicine & Texas Children's Hospital, Houston, TX, USA., Kellermayer R; Department of Pediatrics, Baylor College of Medicine & Texas Children's Hospital, Houston, TX, USA., Savidge TC; Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA. Tor.Savidge@bcm.edu.; Texas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, Houston, TX, USA. Tor.Savidge@bcm.edu.
Jazyk: angličtina
Zdroj: NPJ biofilms and microbiomes [NPJ Biofilms Microbiomes] 2023 Aug 03; Vol. 9 (1), pp. 54. Date of Electronic Publication: 2023 Aug 03.
DOI: 10.1038/s41522-023-00421-4
Abstrakt: Fecal microbiota transplantation (FMT) has proven to be an effective treatment for recurrent Clostridioides difficile infection (rCDI) in both adult and pediatric patients. However, as microbiome development is a critical factor in children, it remains unclear whether adult fecal donors can provide age-appropriate functional restoration in pediatric patients. To address this issue, we conducted an integrated systems approach and found that concordant donor strain engraftment, along with metabolite restoration, are associated with FMT outcomes in both adult and pediatric rCDI patients. Although functional restoration after FMT is not strain-specific, specialized metabolic functions are retained in pediatric patients when adult fecal donors are used. Furthermore, we demonstrated broad utility of high-resolution variant-calling by linking probiotic-strain engraftment with improved gastrointestinal symptoms in adults with irritable bowel syndrome and in children with autism spectrum disorder. Our findings emphasize the importance of strain-level identification when assessing the efficacy of probiotics and microbiota-based therapeutics.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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