Development and regeneration of the vagus nerve.

Autor: Isabella AJ; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: aisabell@umn.edu., Moens CB; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA. Electronic address: cmoens@fredhutch.org.
Jazyk: angličtina
Zdroj: Seminars in cell & developmental biology [Semin Cell Dev Biol] 2024 Mar 15; Vol. 156, pp. 219-227. Date of Electronic Publication: 2023 Aug 01.
DOI: 10.1016/j.semcdb.2023.07.008
Abstrakt: The vagus nerve, with its myriad constituent axon branches and innervation targets, has long been a model of anatomical complexity in the nervous system. The branched architecture of the vagus nerve is now appreciated to be highly organized around the topographic and/or molecular identities of the neurons that innervate each target tissue. However, we are only just beginning to understand the developmental mechanisms by which heterogeneous vagus neuron identity is specified, patterned, and used to guide the axons of particular neurons to particular targets. Here, we summarize our current understanding of the complex topographic and molecular organization of the vagus nerve, the developmental basis of neuron specification and patterned axon guidance that supports this organization, and the regenerative mechanisms that promote, or inhibit, the restoration of vagus nerve organization after nerve damage. Finally, we highlight key unanswered questions in these areas and discuss potential strategies to address these questions.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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