A Shear-Thinning, Self-Healing, Dual-Cross Linked Hydrogel Based on Gelatin/Vanillin/Fe 3+ /AGP-AgNPs: Synthesis, Antibacterial, and Wound-Healing Assessment.

Autor: Talodthaisong C; Materials Chemistry Research Center, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand., Patramanon R; Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand., Thammawithan S; Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand., Lapmanee S; Department of Basic Medical Sciences, Faculty of Medicine, Siam University, Bangkok, 10160, Thailand., Maikaeo L; Nuclear Technology Research and Development Center, Thailand Institute of Nuclear Technology (Public Organization), Nakhon Nayok, 26120, Thailand., Sricharoen P; Department of Premedical Science, Faculty of Medicine, Bangkok, Thonburi University, Thawi Watthana, Bangkok, 10170, Thailand., Khongkow M; National Nanotechnology Centre, National Science and Technology Development Agency, Pathumthani, 12120, Thailand., Namdee K; National Nanotechnology Centre, National Science and Technology Development Agency, Pathumthani, 12120, Thailand., Jantimaporn A; National Nanotechnology Centre, National Science and Technology Development Agency, Pathumthani, 12120, Thailand., Kayunkid N; College of Materials Innovation and Technology, King Mongkut's Institute of Technology Ladkrabang, Ladkrabang, Bangkok, 10520, Thailand., Hutchison JA; School of Chemistry and Centre of Excellence in Exciton Science, The University of Melbourne, Parkville, Victoria, 3010, Australia., Kulchat S; Materials Chemistry Research Center, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand.
Jazyk: angličtina
Zdroj: Macromolecular bioscience [Macromol Biosci] 2023 Dec; Vol. 23 (12), pp. e2300250. Date of Electronic Publication: 2023 Aug 16.
DOI: 10.1002/mabi.202300250
Abstrakt: A shear-thinning and self-healing hydrogel based on a gelatin biopolymer is synthesized using vanillin and Fe 3+ as dual crosslinking agents. Rheological studies indicate the formation of a strong gel found to be injectable and exhibit rapid self-healing (within 10 min). The hydrogels also exhibited a high degree of swelling, suggesting potential as wound dressings since the absorption of large amounts of wound exudate, and optimum moisture levels, lead to accelerated wound healing. Andrographolide, an anti-inflammatory natural product is used to fabricate silver nanoparticles, which are characterized and composited with the fabricated hydrogels to imbue them with anti-microbial activity. The nanoparticle/hydrogel composites exhibit activity against Escherichia coli, Staphylococcus aureus, and Burkholderia pseudomallei, the pathogen that causes melioidosis, a serious but neglected disease affecting southeast Asia and northern Australia. Finally, the nanoparticle/hydrogel composites are shown to enhance wound closure in animal models compared to the hydrogel alone, confirming that these hydrogel composites hold great potential in the biomedical field.
(© 2023 Wiley-VCH GmbH.)
Databáze: MEDLINE
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