A Comparative Study of the Effects of Electronic Cigarette and Traditional Cigarette on the Pulmonary Functions of C57BL/6 Male Mice.

Autor:	Zhao HZ; School of Public Health, Xi'an Medical University, Xi'an, China.; People's Hospital of Shaanxi province, Xi'an, China.; Office of Graduate Student Affairs, Xi'an Medical University, Xi'an, China., Guo ZW; Xi'an Gem Flower Chang Qing Hospital, Xi'an, China.; Department of Basic Medicine, Xi'an Medical University, Xi'an, China., Wang ZL; Department of Basic Medicine, Xi'an Medical University, Xi'an, China.; Institute of Health Sciences, China Medical University, Shenyang, China., Wang C; Department of Basic Medicine, Xi'an Medical University, Xi'an, China.; Institute of Health Sciences, China Medical University, Shenyang, China., Luo XY; Department of Basic Medicine, Xi'an Medical University, Xi'an, China.; Wuxi School of Medicine, Jiangnan University, Wuxi, China., Han NN; Department of Basic Medicine, Xi'an Medical University, Xi'an, China., Li CR; Academy of life sciences, northwestern polytechnical university, Xi'an, China., Zheng HD; Department of Gerontology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Hui ZY; The second clinical medical school of Xi'an Medical University, Xi'an, China., Long Y; The second clinical medical school of Xi'an Medical University, Xi'an, China., Zhao YL; The second clinical medical school of Xi'an Medical University, Xi'an, China., Li QJ; Department of Basic Medicine, Xi'an Medical University, Xi'an, China., Wang SY; School of Public Health, Xi'an Medical University, Xi'an, China.; Department of Basic Medicine, Xi'an Medical University, Xi'an, China.; The First Affiliated Hospital of Xi'an Medical University, Xi'an, China., Zhang GW; School of Public Health, Xi'an Medical University, Xi'an, China.; Department of Basic Medicine, Xi'an Medical University, Xi'an, China.; Office of Graduate Student Affairs, Xi'an Medical University, Xi'an, China.
Jazyk:	angličtina
Zdroj:	Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco [Nicotine Tob Res] 2024 Mar 22; Vol. 26 (4), pp. 474-483.
DOI:	10.1093/ntr/ntad139
Abstrakt:	Introduction: Electronic cigarettes (E-cigs) are in a controversial state. Although E-cig aerosol generally contains fewer harmful substances than smoke from burned traditional cigarettes, aerosol along with other compounds of the E-cigs may also affect lung functions and promote the development of lung-related diseases. We investigated the effects of E-cig on the pulmonary functions of male C57BL/6 mice and reveal the potential underlying mechanisms. Methods: A total of 60 male C57BL/6 mice were randomly divided into four groups. They were exposed to fresh-air, traditional cigarette smoke, E-cig vapor with 12 mg/mL of nicotine, and E-cig with no nicotine for 8 weeks. Lung functions were evaluated by using quantitative analysis of the whole body plethysmograph, FlexiVent system, lung tissue histological and morphometric analysis, and RT-PCR analysis of mRNA expression of inflammation-related genes. In addition, the effects of nicotine and acrolein on the survival rate and DNA damage were investigated using cultured human alveolar basal epithelial cells. Results: Exposure to E-cig vapor led to significant changes in lung functions and structures including the rupture of the alveolar cavity and enlarged alveolar space. The pathological changes were also accompanied by increased expression of interleukin-6 and tumor necrosis factor-α. Conclusions: The findings of the present study indicate that the safety of E-cig should be further evaluated. Implications: Some people currently believe that using nicotine-free E-cigs is a safe way to smoke. However, our research shows that E-cigs can cause lung damage regardless of whether they contain nicotine. (© The Author(s) 2023. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu