Frequency and imaging correlates of neuropsychiatric symptoms in Progressive Supranuclear Palsy.

Autor: Cuoco S; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Neuroscience Section, Via Allende, 84081, Baronissi (Salerno), Italy., Ponticorvo S; Center for Magnetic Resonance Research (CMRR), Department of Radiology, University of Minnesota, 2021 6th St. SE, Minneapolis, MN, 55455, USA., Abate F; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Neuroscience Section, Via Allende, 84081, Baronissi (Salerno), Italy., Tepedino MF; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Neuroscience Section, Via Allende, 84081, Baronissi (Salerno), Italy., Erro R; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Neuroscience Section, Via Allende, 84081, Baronissi (Salerno), Italy., Manara R; Department of Neurosciences, Neuroradiology Unit, University of Padua, 35128, Padua, Italy., Di Salle G; Scuola Superiore Di Studi Universitari E Perfezionamento Sant'Anna, Classe Di Scienze Sperimentali, Pisa, Italy., Di Salle F; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Neuroscience Section, Via Allende, 84081, Baronissi (Salerno), Italy., Pellecchia MT; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Neuroscience Section, Via Allende, 84081, Baronissi (Salerno), Italy., Esposito F; Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', 80138, Naples, Italy., Barone P; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Neuroscience Section, Via Allende, 84081, Baronissi (Salerno), Italy., Picillo M; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Neuroscience Section, Via Allende, 84081, Baronissi (Salerno), Italy. mpicillo@unisa.it.
Jazyk: angličtina
Zdroj: Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2023 Oct; Vol. 130 (10), pp. 1259-1267. Date of Electronic Publication: 2023 Aug 03.
DOI: 10.1007/s00702-023-02676-9
Abstrakt: Neuropsychiatric symptoms are intrinsic to Progressive Supranuclear Palsy (PSP) and a spoonful of studies investigated their imaging correlates. Describe (I) the frequency and severity of neuropsychiatric symptoms in PSP and (II) their structural imaging correlates. Twenty-six PSP patients underwent Neuropsychiatric Inventory (NPI) and brain 3D T1-weighted MRI. Spearman's rho with Bonferroni correction was used to investigate correlations between NPI scores and volumes of gray matter regions. More than 80% of patients presented at least one behavioral symptom of any severity. The most frequent and severe were depression/dysphoria, apathy, and irritability/lability. Significant relationships were found between the severity of irritability and right pars opercularis volume (p < 0.001) as well as between the frequency of agitation/aggression and left lateral occipital volume (p < 0.001). Depression, apathy, and irritability are the most common neuropsychiatric symptoms in PSP. Moreover, we found a relationship between specific positive symptoms as irritability and agitation/aggression and greater volume of the right pars opercularis cortex and lower volume of the left occipital cortex, respectively, which deserve further investigations.
(© 2023. The Author(s).)
Databáze: MEDLINE
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