Association between the rs1036819 polymorphism of the ZFAT gene and pelvic organ prolapse: a case-control study.

Autor: da Silva RSP; Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil. rebeccasotelo.go@gmail.com.; Hospital Federal de Ipanema - Setor de Ginecologia, Rua Antônio Parreiras, 67 - 4º andar, CEP: 22411-020, Rio de Janeiro, RJ, Brazil. rebeccasotelo.go@gmail.com., Bortolini MAT; Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil., Teixeira JB; Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil., Batista NC; Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil., Fitz FF; Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil., Allen-Brady K; Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA., Castro RA; Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: International urogynecology journal [Int Urogynecol J] 2023 Oct; Vol. 34 (10), pp. 2611-2617. Date of Electronic Publication: 2023 Aug 03.
DOI: 10.1007/s00192-023-05615-0
Abstrakt: Introduction and Hypothesis: The identification of risk factors for pelvic organ prolapse (POP) would contribute to planning prevention strategies. This study tests the hypothesis that the rs1036819 polymorphism in the ZFAT gene is associated with POP and investigates other risk factors for prolapse development.
Methods: A case-control study was carried out including 826 postmenopausal women divided into POP cases (stages III and IV) and controls (stages 0 and I), assessed by anamnesis, examination, and peripheral blood samples. DNA was extracted from blood and genotyped by real-time RT-PCR. We used logistic regression models for the association analyses of variables, with p < 0.05 for significance.
Results: Five hundred and sixty-eight women were evaluated (315 POP and 253 controls). The minor allele C was found in 19.3% of our sample and the genotype frequencies of AA, AC, and CC were similar in both groups. Age (OR 1.09, 95% CI 1.06-1.13), number of pregnancies (OR 1.23, 95% CI 1.08-1.41), history of one vaginal delivery (OR 3.39, 95% CI 1.38-8.33) or two or more (OR 2.51, 95% CI 1.04-6.07), weight of the largest newborn (OR 1.0001, 95% CI 1-1.001), and family history of POP (OR 2.27, 95% CI 1.24-4.13) were independent risk factors for POP, whereas one cesarean section (OR 0.48, 95% CI 0.27-0.88) or two or more (OR 0.14, 95% CI 0.05-0.38) were protective.
Conclusions: No association was detected between the rs1036819 polymorphism of the ZFAT gene and advanced POP. Age, number of pregnancies, at least one vaginal delivery, weight of the newborn, and POP family history were independent risk factors for POP.
(© 2023. The International Urogynecological Association.)
Databáze: MEDLINE
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