Response investigation of a new polymer gel dosimeter based on ammonium salt through MRI technique.

Autor: Goosheh A; Department of Physics, Payame Noor University, Tehran, Iran., Abtahi SMM; Department of Physics, Imam Khomeini International University, Qazvin, Iran. Electronic address: sm.abtahi@sci.ikiu.ac.ir., Mahdavi SR; Department of Medical Physics, School of Medicine, Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Jazyk: angličtina
Zdroj: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2023 Oct; Vol. 200, pp. 110956. Date of Electronic Publication: 2023 Jul 23.
DOI: 10.1016/j.apradiso.2023.110956
Abstrakt: Increasing the use of polymer gel dosimetry (PGD) in radiotherapy requires reducing its toxicity. The toxicity of the PGD components causes risks for the users as well as the environment. The aim of this study is to produce a new PGD called PAGBIT (Polymer, Amps ammonium salt, Gelatin, BIs, Thpc) based on the nontoxic monomer of 2-acrylamido-2-methylpropanesulfonic acid ammonium salt. Furthermore, this monomer is ecofriendly. The PAGBIT PGD was prepared in the laboratory in ambient conditions. PGDs were irradiated using a clinical accelerator with a dose range of 0-10 Gy. The incident photon energy and dose rate were 6-MV and 300 cGy/min, respectively. The irradiated PGDs were imaged using a 1.5T MRI scanner 9 times in a time range of 12-720 h post-irradiation. The maximum obtained sensitivity was 0.115 ± 0.005 Gy -1 s -1  at 36 h post-irradiation time. The average sensitivity change as a function of post-irradiation time was 0.0017 Gy -1 s -1 h -1 . However, the average sensitivity change as a function of scanning temperature was 0.0006 Gy -1 s -1 °C -1 . Results showed that the differences of effective atomic number and electron density between PAGBIT and soft tissue were 2.3% and 0.3%, respectively. It was concluded that the PAGBIT is a low toxic, water equivalent PGD with noticeable temporal and temperature stabilities.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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