Chemical Composition, Mosquito Larvicidal and Antimicrobial Activities, and Molecular Docking Study of Essential Oils of Cinnamomum melastomaceum, Neolitsea buisanensis and Uvaria microcarpa from Vietnam.

Autor: Pham TV; Faculty of Chemistry, University of Education, Hue University, 34 Le Loi, Hue, 530000, Vietnam., Ha NX; Institute of Natural Products Chemistry, VAST, 18 Hoang Quoc Viet, Caugiay, 10000, Hanoi, Vietnam., Luyen ND; Institute of Natural Products Chemistry, VAST, 18 Hoang Quoc Viet, Caugiay, 10000, Hanoi, Vietnam., Xuan TH; Faculty of Biology, University of Education, Hue University, 34 Le Loi, Hue, 530000, Vietnam., Le Quoc T; Faculty of Chemistry, University of Education, Hue University, 34 Le Loi, Hue, 530000, Vietnam., Hung NH; Center for Advanced Chemistry, Institute of Research and Development, Duy Tan University, 03 Quang Trung, Danang, 550000, Vietnam.; Department of Pharmacy, Duy Tan University, 03 Quang Trung, Danang, 550000, Vietnam., The SN; Institute of Chemistry, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, 10000, Vietnam.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2023 Sep; Vol. 20 (9), pp. e202300652. Date of Electronic Publication: 2023 Aug 18.
DOI: 10.1002/cbdv.202300652
Abstrakt: The leaf oil compositions of two Lauraceae and one Annonaceae plants cultivated in Vietnam were analysed by GC/MS (gas chromatography-mass spectrometry) analysis. The leaf oil of the first Lauraceae plant Cinnamomum melastomaceum contained 34 identified compounds, in which benzyl benzoate (38.5 %), linalool (19.9 %), (E)-caryophyllene (10.5 %), and α-terpineol (6.9 %) were the major compounds. The leaves of the second Lauraceae plant Neolitsea buisanensis gave an oil with the main compounds (E)-β-ocimene (24.0 %), benzyl benzoate (15.8 %), bicyclogermacrene (14.9 %), and (E)-caryophyllene (6.3 %). The leaf oil of the Annonaceae plant Uvaria microcarpa consisted of the principal compounds (E)-caryophyllene (18.0 %), bicyclogermacrene (8.1 %), and δ-elemene (6.1 %). Two Lauraceae oil samples exhibited strong mosquito larvicidal activity against Aedes aegypti, Ae. albopictus, and Culex quinquefasciatus with LC 50 and LD 90 values of less than 50 μg/mL. The Annonaceae oil sample showed strong antimicrobial activity against the fungus Aspergillus niger ATCC 1015 with the MIC (minimum inhibitory concentration) value of 32 μg/mL. In the docking approach, the major compounds (E)-caryophyllene, bicyclogermacrene, and benzyl benzoate interacted with the mosquito odorant-binding protein 3OGN, whereas (E)-caryophyllene, bicyclogermacrene, and δ-elemene also potentially interacted with the 4ZA5 protein of fungus A. niger.
(© 2023 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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