| Autor: |
Kitano J, Ansai S, Fujimoto S, Kakioka R, Sato M, Mandagi IF, Sumarto BKA, Yamahira K |
| Jazyk: |
angličtina |
| Zdroj: |
The American naturalist [Am Nat] 2023 Aug; Vol. 202 (2), pp. 231-240. Date of Electronic Publication: 2023 Jun 16. |
| DOI: |
10.1086/724840 |
| Abstrakt: |
AbstractSex chromosomes rapidly turn over in several taxonomic groups. Sex chromosome turnover is generally thought to start with the appearance of a new sex-determining gene on an autosome while an old sex-determining gene still exists, followed by the fixation of the new one. However, we do not know how prevalent the transient state is, where multiple sex-determining loci coexist within natural populations. Here, we removed a Y chromosome with a master male-determining gene DMY from medaka fish using high temperature-induced sex-reversed males. After four generations, the genomic characteristics of a sex chromosome were found on one chromosome, which was an autosome in the original population. Thus, the elimination of a master sex-determining locus can reveal a cryptic locus with a possible sex-determining effect, which can be the seed for sex chromosome turnover. Our results suggest that populations that seem to have a single-locus XY system may have other chromosomal regions with sex-determining effects. In conclusion, the coexistence of multiple sex-determining genes in a natural population may be more prevalent than previously thought. Experimental elimination of a master sex-determining locus may serve as a promising method for finding a locus that can be a protosex chromosome. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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