Transspinal Focused Ultrasound Suppresses Spinal Reflexes in Healthy Rats.

Autor: Song W; Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Manhasset, NY, USA., Jayaprakash N; Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Manhasset, NY, USA., Saleknezhad N; Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Manhasset, NY, USA., Puleo C; General Electric Research, Niskayuna, NY, USA., Al-Abed Y; Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Manhasset, NY, USA., Martin JH; Department of Molecular, Cellular, and Biomedical Sciences, Center for Discovery and Innovation, City University of New York School of Medicine, New York, NY, USA., Zanos S; Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Manhasset, NY, USA; Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY; Elmezzi Graduate School of Molecular Medicine, Manhasset, NY. Electronic address: szanos@northwell.edu.
Jazyk: angličtina
Zdroj: Neuromodulation : journal of the International Neuromodulation Society [Neuromodulation] 2024 Jun; Vol. 27 (4), pp. 614-624. Date of Electronic Publication: 2023 Aug 02.
DOI: 10.1016/j.neurom.2023.04.476
Abstrakt: Objectives: Low-intensity, focused ultrasound (FUS) is an emerging noninvasive neuromodulation approach, with improved spatial and temporal resolution and penetration depth compared to other noninvasive electrical stimulation strategies. FUS has been used to modulate circuits in the brain and the peripheral nervous system, however, its potential to modulate spinal circuits is unclear. In this study, we assessed the effect of trans-spinal FUS (tsFUS) on spinal reflexes in healthy rats.
Materials and Methods: tsFUS targeting different spinal segments was delivered for 1 minute, under anesthesia. Monosynaptic H-reflex of the sciatic nerve, polysynaptic flexor reflex of the sural nerve, and withdrawal reflex tested with a hot plate were measured before, during, and after tsFUS.
Results: tsFUS reversibly suppresses the H-reflex in a spinal segment-, acoustic pressure- and pulse-repetition frequency (PRF)-dependent manner. tsFUS with high PRF augments the degree of homosynaptic depression of the H-reflex observed with paired stimuli. It suppresses the windup of components of the flexor reflex associated with slower, C-afferent, but not faster, A- afferent fibers. Finally, it increases the latency of the withdrawal reflex. tsFUS does not elicit neuronal loss in the spinal cord.
Conclusions: Our study provides evidence that tsFUS reversibly suppresses spinal reflexes and suggests that tsFUS could be a safe and effective strategy for spinal cord neuromodulation in disorders associated with hyperreflexia, including spasticity after spinal cord injury and painful syndromes.
Competing Interests: Conflict of Interest The authors reported no conflict of interest.
(Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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