The prognostic values of the IL-10 (G1082A) and TNF-α (G308A) polymorphisms in Egyptian patients with acute lymphoblastic leukemia: A single-center study.

Autor:	El Baiomy MA; Department of Internal Medicine, Medical Oncology Unit, Mansoura University Oncology Center, Mansoura, Egypt., Akl T; Department of Internal Medicine, Medical Oncology Unit, Mansoura University Oncology Center, Mansoura, Egypt., ElMenshawy N; Clinical Pathology Department, Hematology Unit, Mansoura University, Mansoura, Egypt., El-Sebaie AH; Clinical Pathology Department, Hematology Unit, Mansoura University, Mansoura, Egypt., Morkos H; Clinical Pathology Department, Hematology Unit, Mansoura University, Mansoura, Egypt., El-Ashwah S; Department of Internal Medicine, Clinical Hematology Unit, Mansoura University Oncology Center, Mansoura, Egypt., El-Sabbagh AM; Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Egypt., Wahba Y; Department of Pediatrics, Genetics Unit, Faculty of Medicine, Mansoura University, Egypt., El-Ghonemy M; Clinical Pathology Department, Hematology Unit, Mansoura University, Mansoura, Egypt.
Jazyk:	angličtina
Zdroj:	Indian journal of cancer [Indian J Cancer] 2023 Apr-Jun; Vol. 60 (2), pp. 217-223.
DOI:	10.4103/ijc.IJC_102_21
Abstrakt:	Background: Interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-α) genes contribute to oncogenesis. We evaluated the influence of the IL-10 (G1082A) and TNF-α (G308A) polymorphisms on the prognosis and outcomes of Egyptian patients with acute lymphoblastic leukemia (ALL). Materials and Methods: We investigated 64 children and 76 adults with ALL, between 2016 and 2019, for the IL-10 (G1082A) and TNF-α (G308A) polymorphisms using allele-specific polymerase chain reaction and polymerase chain reaction-restriction fragment length polymorphism. Survival analyses were performed using the Kaplan-Meier estimator and the log-rank test. Results: In children with ALL, the A allele of TNF-α and IL-10 polymorphisms was associated with older age (P = 0.04 and 0.03), more extramedullary disease (P = 0.02 and 0.001), positive breakpoint cluster region-Abelson (BCR-ABL) rearrangement (p190; P = 0.04 and 0.001), and more relapse (P = 0.002). The IL-10 GG genotype was associated with higher overall survival in children (P = 0.026). Adults carrying the TNF-α A allele showed more extramedullary disease (P = 0.009) and relapse (P = 0.003). We also found a higher frequency of IL-10 A allele in adults with older age (P = 0.03), lower hemoglobin level (P = 0.04), positive BCR-ABL rearrangement (P = 0.001), more extramedullary disease (P = 0.001), more relapse (P = 0.002), and a longer time for the first complete remission (P = 0.003). Conclusion: A possible association exists between the A allele of IL-10 and TNF-α polymorphisms and poor prognosis in Egyptian patients with ALL, while the IL-10 GG genotype may be associated with better survival in children with ALL.
Databáze:	MEDLINE
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