Role of Cutaneous Microbiome in Dermatology.

Autor: Mustari AP; From the Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Agarwal I; Department of Dermatology, IMS and SUM Hospital, Bhubaneshwar, Orissa, India., Das A; Department of Dermatology, KPC Medical College and Hospital, Kolkata, West Bengal, India., Vinay K; From the Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Jazyk: angličtina
Zdroj: Indian journal of dermatology [Indian J Dermatol] 2023 May-Jun; Vol. 68 (3), pp. 303-312.
DOI: 10.4103/ijd.ijd_560_22
Abstrakt: The cutaneous microflora consists of various microorganisms which interact with host epithelial cells and innate and acquired immunity. This microbial milieu and its interaction with host cells prevent the growth of pathogenic organisms and educate host immunity to fight against harmful microorganisms. The microbial composition depends on various intrinsic and extrinsic factors and an imbalance in the cutaneous microflora predisposes the individual to both infectious and non-infectious diseases. Even though probiotics have been extensively studied in various diseases, their efficacy and safety profile are still unclear. A better understanding of the cutaneous microflora is required to develop newer therapeutic targets. In this review, we describe the commensal microbiome and its variation, the current role of the cutaneous microbiome in the pathogenesis of various dermatological diseases, and their therapeutic implications.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2023 Indian Journal of Dermatology.)
Databáze: MEDLINE
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