Recent developments in natural biopolymer based drug delivery systems.

Autor:	Fazal T; Department of Chemistry, Abbottabad University of Science and Technology Pakistan tanzeelafazal@yahoo.com., Murtaza BN; Department of Zoology, Abbottabad University of Science and Technology Pakistan., Shah M; Department of Chemistry, Faculty of Science, Grand Asian University Sialkot Pakistan., Iqbal S; Department of Chemistry, School of Natural Sciences (SNS), National University of Science and Technology (NUST) H-12 Islamabad 46000 Pakistan shahidgcs10@yahoo.com., Rehman MU; Department of Microbiology, Abbottabad University of Science & Technology Pakistan., Jaber F; Department of Biomedical Engineering, Ajman University Ajman UAE.; Center of Medical and Bio-Allied Health Sciences Research, Ajman University Ajman UAE., Dera AA; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University Abha Saudi Arabia., Awwad NS; Chemistry Department, Faculty of Science, King Khalid University P.O. Box 9004 Abha 61413 Saudi Arabia., Ibrahium HA; Biology Department, Faculty of Science, King Khalid University P.O. Box 9004 Abha 61413 Saudi Arabia.
Jazyk:	angličtina
Zdroj:	RSC advances [RSC Adv] 2023 Jul 31; Vol. 13 (33), pp. 23087-23121. Date of Electronic Publication: 2023 Jul 31 (Print Publication: 2023).
DOI:	10.1039/d3ra03369d
Abstrakt:	Targeted delivery of drug molecules to diseased sites is a great challenge in pharmaceutical and biomedical sciences. Fabrication of drug delivery systems (DDS) to target and/or diagnose sick cells is an effective means to achieve good therapeutic results along with a minimal toxicological impact on healthy cells. Biopolymers are becoming an important class of materials owing to their biodegradability, good compatibility, non-toxicity, non-immunogenicity, and long blood circulation time and high drug loading ratio for both macros as well as micro-sized drug molecules. This review summarizes the recent trends in biopolymer-based DDS, forecasting their broad future clinical applications. Cellulose chitosan, starch, silk fibroins, collagen, albumin, gelatin, alginate, agar, proteins and peptides have shown potential applications in DDS. A range of synthetic techniques have been reported to design the DDS and are discussed in the current study which is being successfully employed in ocular, dental, transdermal and intranasal delivery systems. Different formulations of DDS are also overviewed in this review article along with synthesis techniques employed for designing the DDS. The possibility of these biopolymer applications points to a new route for creating unique DDS with enhanced therapeutic qualities for scaling up creative formulations up to the clinical level. Competing Interests: The authors declare no conflict of interest. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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