Urinary incontinence-related effects on functional connectivity circuits in persons with Parkinson's disease.

Autor: Denmon C; Center for Visual & Neurocognitive Rehabilitation, Atlanta VA Medical Center, Decatur, Georgia, USA., Wakeman DG; Center for Visual & Neurocognitive Rehabilitation, Atlanta VA Medical Center, Decatur, Georgia, USA., Vernon M; Center for Visual & Neurocognitive Rehabilitation, Atlanta VA Medical Center, Decatur, Georgia, USA., McGregor K; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.; Birmingham/Atlanta VA Geriatric Research Education and Clinical Center, Birmingham, Alabama, USA., Krishnamurthy V; Center for Visual & Neurocognitive Rehabilitation, Atlanta VA Medical Center, Decatur, Georgia, USA.; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA., Krishnamurthy L; Center for Visual & Neurocognitive Rehabilitation, Atlanta VA Medical Center, Decatur, Georgia, USA.; Department of Physics & Astronomy, Georgia State University, Atlanta, Georgia, USA.; Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia, USA., Stevens J; Center for Visual & Neurocognitive Rehabilitation, Atlanta VA Medical Center, Decatur, Georgia, USA.; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA., Vaughan CP; Center for Visual & Neurocognitive Rehabilitation, Atlanta VA Medical Center, Decatur, Georgia, USA.; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.; Birmingham/Atlanta VA Geriatric Research Education and Clinical Center, Atlanta, Georgia, USA.
Jazyk: angličtina
Zdroj: Neurourology and urodynamics [Neurourol Urodyn] 2023 Nov; Vol. 42 (8), pp. 1694-1701. Date of Electronic Publication: 2023 Aug 02.
DOI: 10.1002/nau.25258
Abstrakt: Introduction: Urinary incontinence (UI) is a common and disruptive symptom of Parkinson's disease (PD). This study aimed to identify neural correlates associated with UI among PD patients with UI (UI-PD) compared to those PD patients without UI (nonUI-PD) with the expectation of demonstrating increased functional connectivity (FC) between areas in the striatum and limbic system and decreased FC in executive areas.
Methods: rsfMRI and T1w data (n = 119) were retrieved from the Parkinson's Progression Markers Initiative (PPMI). Resting-state FC analyses assessed temporal covariance with anterior cingulate gyrus, precuneus, and putamen seed regions.
Results: The UI-PD group (n = 32, 16 females) showed significantly greater positive FC between the bilateral putamen seed and the right caudate and right thalamus (p < 0.01), relative to individuals with PD but who did not have UI (n = 87, 18 females). The UI-PD group showed greater negative FC between the anterior cingulate seed and right angular gyrus (p < 0.01) relative to nonUI-PD.
Conclusion: Individuals with PD and UI display stronger FC within neural circuits likely affected by PD such as between the putamen and caudate, as well as within those associated with brain bladder control, compared to persons with PD and without UI. Clinical application based on this study's results can provide greater discernment of treatment strategies for UI-PD patients.
(Published 2023. This article is a U.S. Government work and is in the public domain in the USA. Neurourology and Urodynamics published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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