Long-term influenza antibodies profiles in previously vaccinated and non-vaccinated adults.

Autor:	Sanz-Muñoz I; National Influenza Centre, Hospital Clinico Universitario de Valladolid, Valladolid, Spain.; Instituto de Estudios de Ciencias de la Salud de Castilla y León, ICSCYL, Soria, Spain.; CIBERINFEC, Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain., Lajara C; Renault España S.A., Valladolid and Palencia Factories, Valladolid, Spain., Sánchez-Martínez J; National Influenza Centre, Hospital Clinico Universitario de Valladolid, Valladolid, Spain.; Instituto de Estudios de Ciencias de la Salud de Castilla y León, ICSCYL, Soria, Spain., Prada-García C; Department of Preventive Medicine and Public Health, University of Valladolid, Valladolid, Spain., Rojo-Rello S; National Influenza Centre, Hospital Clinico Universitario de Valladolid, Valladolid, Spain.; Microbiology Unit, Hospital Clínico Universitario de Valladolid, Valladolid, Spain., Domínguez-Gil M; National Influenza Centre, Hospital Clinico Universitario de Valladolid, Valladolid, Spain.; Microbiology Unit, Hospital Universitario Río Hortega, Valladolid, Spain., Fernández-Espinilla V; National Influenza Centre, Hospital Clinico Universitario de Valladolid, Valladolid, Spain.; Preventive Medicine and Public Health Unit, Hospital Clínico Universitario de Valladolid, Valladolid, Spain., Hernán-García C; National Influenza Centre, Hospital Clinico Universitario de Valladolid, Valladolid, Spain.; Preventive Medicine and Public Health Unit, Hospital Clínico Universitario de Valladolid, Valladolid, Spain., Eiros-Bachiller JM; Pneumology Unit, Hospital Universitario de la Princesa, Madrid, Spain., Caminero-Pérez A; Renault España S.A., Valladolid and Palencia Factories, Valladolid, Spain., Marcos-López Y; Renault España S.A., Valladolid and Palencia Factories, Valladolid, Spain., Teso-Fernández L; Renault España S.A., Valladolid and Palencia Factories, Valladolid, Spain., Echarren JI; Renault España S.A., Valladolid and Palencia Factories, Valladolid, Spain., Castrodeza-Sanz J; National Influenza Centre, Hospital Clinico Universitario de Valladolid, Valladolid, Spain.; Preventive Medicine and Public Health Unit, Hospital Clínico Universitario de Valladolid, Valladolid, Spain., Eiros JM; National Influenza Centre, Hospital Clinico Universitario de Valladolid, Valladolid, Spain.; Microbiology Unit, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.; Microbiology Unit, Hospital Universitario Río Hortega, Valladolid, Spain.
Jazyk:	angličtina
Zdroj:	Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2023 Aug 01; Vol. 19 (2), pp. 2236537.
DOI:	10.1080/21645515.2023.2236537
Abstrakt:	The aim of this work is to describe the dynamics of influenza antibodies after vaccination in adults. We conducted a case-cohort serological study in the automobile manufacturing plants of the Renault España S.A. group in Valladolid and Palencia (Spain), including 550 workers (66.9%) previously vaccinated against influenza (group V), and 272 (33.1%) never vaccinated (group NV). A pre-vaccination serum sample was collected, another after 30-40 days and another after 6 months. The dynamics of antibodies were analyzed. A lower seroprotection of NV before vaccination was observed, but an antibody response between 2 and 4 times higher than in V was assessed. After 6 months, antibodies declined in both groups until equalize. Antibodies titers decrease with age, and no differences were found among underlying pathologies. Adults never vaccinated against influenza had lower seroprotection than those previously vaccinated, but influenza vaccination produces a more intense serological response in them, acquiring significantly higher antibody titers than those previously vaccinated. The antibodies, although in lower titers, persist and equalize among both groups at least 6 months after vaccination, which allows the individual to be protected during the entire circulation of the influenza virus in the same season.
Databáze:	MEDLINE
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