Photobiomodulation in diabetic rats: Effects on morphological, pancreatic parameters, and glucose homeostasis.

Autor: Pandolfo IL; Department of Biosciences, Institute of Health and Society, Federal University of São Paulo (UNIFESP), Santos, Brazil., Bonifacio M; Department of Biosciences, Institute of Health and Society, Federal University of São Paulo (UNIFESP), Santos, Brazil., Benfato ID; Department of Biosciences, Institute of Health and Society, Federal University of São Paulo (UNIFESP), Santos, Brazil., de Almeida Cruz M; Department of Biosciences, Institute of Health and Society, Federal University of São Paulo (UNIFESP), Santos, Brazil., Nagaoka MR; Department of Biosciences, Institute of Health and Society, Federal University of São Paulo (UNIFESP), Santos, Brazil., Carvalho CPF; Department of Biosciences, Institute of Health and Society, Federal University of São Paulo (UNIFESP), Santos, Brazil., de Oliveira CAM; Department of Biosciences, Institute of Health and Society, Federal University of São Paulo (UNIFESP), Santos, Brazil., Renno ACM; Department of Biosciences, Institute of Health and Society, Federal University of São Paulo (UNIFESP), Santos, Brazil.
Jazyk: angličtina
Zdroj: Journal of biophotonics [J Biophotonics] 2023 Nov; Vol. 16 (11), pp. e202300182. Date of Electronic Publication: 2023 Aug 22.
DOI: 10.1002/jbio.202300182
Abstrakt: Photobiomodulation (PBM) has therapeutic effects on wound healing, diabetic microangiopathy, and retinopathy. However, little is known about the use of PBM for the treatment of diabetes mellitus (DM). In this context, we aimed to evaluate the effects of PBM on pancreas morphology and insulin and glucose tolerance in an experimental model of DM. Thus, DM was induced by streptozotocin (STZ) (60 mg/kg). Subsequently, the rats were treated with PBM (808 nm and 30 J/cm 2 ). After euthanasia, morphometric parameters and immunoreactivity for insulin and 8-OHdG were evaluated in the pancreas. The results showed that treated animals had higher values of body mass and higher values in the number of beta cells in the pancreas. In conclusion, PBM resulted in decreased weight loss in STZ-induced diabetic rats and presented a stimulatory effect on the pancreas of the treated animals, highlighting the promising effects of this therapy in the clinical condition of DM.
(© 2023 Wiley-VCH GmbH.)
Databáze: MEDLINE
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