Proteome of urticating setae of Ochrogaster lunifer, a processionary caterpillar of medical and veterinary importance, including primary structures of putative toxins.

Autor: Walker AA; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.; Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, St Lucia, Queensland, Australia., Perkins LE; School of Biological Sciences, The University of Queensland, St Lucia, Queensland, Australia., Battisti A; Department of Agronomy, Food, Natural Resources, Animals and the Environment, University of Padova, Padova, Italy., Zalucki MP; School of Biological Sciences, The University of Queensland, St Lucia, Queensland, Australia., King GF; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.; Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, St Lucia, Queensland, Australia.
Jazyk: angličtina
Zdroj: Proteomics [Proteomics] 2023 Oct; Vol. 23 (20), pp. e2300204. Date of Electronic Publication: 2023 Aug 01.
DOI: 10.1002/pmic.202300204
Abstrakt: Ochrogaster lunifer (Lepidoptera: Notodontidae) is an Australian processionary caterpillar with detachable urticating setae that have a defensive function. These true setae induce inflammation when they contact human skin, and equine foetal loss syndrome if they are accidentally ingested by gravid horses. We used transcriptomics and proteomics to identify proteins and peptides present in and on urticating setae, which may include toxins that contribute to inflammation and/or foetal loss syndromes. This process identified 37 putative toxins, including multiple homologues of the honeybee venom peptide secapin, and proteins with similarity to odorant binding proteins, arylphorins, and the insect immune modulator Diedel. This work identifies candidate molecules that may contribute to the adverse effects of processionary caterpillar setae on human and animal health.
(© 2023 The Authors. Proteomics published by Wiley-VCH GmbH.)
Databáze: MEDLINE
Externí odkaz: