Is lysosomal acid lipase activity associated with the presence and severity of coronary artery disease?

Autor: Kızıltunç E; Department of Cardiology. Emniyet, Gazi University School of Medicine, 06560, Ankara, Yenimahalle, Turkey. e.kiziltunc@gmail.com., Gökalp S; Department of Pediatric Metabolism and Nutrition, Gazi University School of Medicine, Ankara, Turkey., Biberoğlu G; Department of Pediatric Metabolism and Nutrition, Gazi University School of Medicine, Ankara, Turkey., Yalçın Y; Department of Cardiology. Emniyet, Gazi University School of Medicine, 06560, Ankara, Yenimahalle, Turkey., Cihan B; Department of Cardiology. Emniyet, Gazi University School of Medicine, 06560, Ankara, Yenimahalle, Turkey., Öktem RM; Department of Pediatric Metabolism and Nutrition, Gazi University School of Medicine, Ankara, Turkey., İnci A; Department of Pediatric Metabolism and Nutrition, Gazi University School of Medicine, Ankara, Turkey., Tümer L; Department of Pediatric Metabolism and Nutrition, Gazi University School of Medicine, Ankara, Turkey., Yalçın MR; Department of Cardiology. Emniyet, Gazi University School of Medicine, 06560, Ankara, Yenimahalle, Turkey., Abacı A; Department of Cardiology. Emniyet, Gazi University School of Medicine, 06560, Ankara, Yenimahalle, Turkey.
Jazyk: angličtina
Zdroj: Herz [Herz] 2024 Feb; Vol. 49 (1), pp. 75-80. Date of Electronic Publication: 2023 Aug 01.
DOI: 10.1007/s00059-023-05200-7
Abstrakt: Background: Lipid metabolism is considerably complex and there can be many critical steps in atherogenesis. The association between lysosomal acid lipase (LAL) activity and coronary artery disease (CAD) has not been elucidated in detail. We aimed to evaluate the association between LAL activity with the presence and severity of CAD in patients who are seen in daily clinical practice.
Methods: Patients who underwent coronary angiography were divided into groups according to the angiography results. Syntax scores and Gensini scores were calculated. The LAL activity was measured from dried blood spots.
Results: Median LAL activity values were similar in all study groups (normal coronary arteries: 0.40 nmol/punch/h; non-obstructive CAD: 0.44 nmol/punch/h; obstructive chronic CAD: 0.40 nmol/punch/h; obstructive acute coronary syndrome: 0.48 nmol/punch/h) and there was no correlation between coronary atherosclerotic burden and LAL activity (correlation coefficients Syntax score and LAL: -0.032; Gensini score and LAL: -0.030). In addition, no relationship between serum lipid levels and LAL activity was detected.
Conclusion: The presence of CAD and its severity is not associated with the LAL activity in patients encountered in daily clinical practice.
(© 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
Databáze: MEDLINE
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