Prenatal depression and risk of child autism-related traits among participants in the Environmental influences on Child Health Outcomes program.

Autor: Avalos LA; Division of Research, Kaiser Permanente Northern California, Oakland, California, USA., Chandran A; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA., Churchill ML; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA., Gao X; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA., Ames JL; Division of Research, Kaiser Permanente Northern California, Oakland, California, USA., Nozadi SS; Department of Pharmaceutical Sciences, Health Sciences Center, University of New Mexico, Albuquerque, New Mexico, USA., Roubinov D; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA., Brennan PA; Department of Psychology, Emory University, Atlanta, Georgia, USA., Bush NR; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA.; Department of Pediatrics, University of California, San Francisco, California, USA., Camargo CA; Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Carroll KN; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Cioffi CC; Prevention Science Institute, University of Oregon, Eugene, Oregon, USA., Ferrara A; Division of Research, Kaiser Permanente Northern California, Oakland, California, USA., Goldson B; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Hedderson MM; Division of Research, Kaiser Permanente Northern California, Oakland, California, USA., Hipwell AE; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Kerver JM; Departments of Epidemiology & Biostatistics, Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, Michigan, USA., O'Connor TG; Departments of Psychiatry, Psychology, Neuroscience, Obstetrics and Gynecology, University of Rochester, Rochester, New York, USA., Porucznik CA; Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, Utah, USA., Shuffrey LC; Department of Psychiatry, Columbia University Medical Center, New York, New York, USA., Talavera-Barber MM; Avera McKennan Hospital and University Health Center, Avera Research Institute, Sioux Falls, South Dakota, USA., Wright RJ; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Zhu Y; Division of Research, Kaiser Permanente Northern California, Oakland, California, USA., Croen LA; Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Jazyk: angličtina
Zdroj: Autism research : official journal of the International Society for Autism Research [Autism Res] 2023 Sep; Vol. 16 (9), pp. 1825-1835. Date of Electronic Publication: 2023 Aug 01.
DOI: 10.1002/aur.2988
Abstrakt: This study evaluated the association between prenatal depression and offspring autism-related traits. The sample comprised 33 prenatal/pediatric cohorts participating in the Environmental influences on Child Health Outcomes program who contributed information on prenatal depression and autism-related traits. Autism-related traits were assessed continuously and at the diagnostic cut-off using the Social Responsiveness Scale for children up to 12 years of age. Main analyses included 3994 parent-child pairs with prenatal depression diagnoses data; secondary analyses included 1730 parent-child pairs with depression severity data. After confounder adjustment, we observed an increase in autism-related traits among children of individuals with prenatal depression compared to those without (adjusted β = 1.31 95% CI: 0.65, 1.98). Analyses stratified by child sex documented a similar significant association among boys (aβ = 1.34 95%CI: 0.36, 2.32) and girls (aβ = 1.26 95% CI: 0.37, 2.15). Prenatal depression was also associated with increased odds of moderate to severe autism-related traits (adjusted odds ratio: 1.64, 95%CI: 1.09, 2.46), the screening threshold considered high risk of autism spectrum disorder (ASD) diagnosis. Findings highlight the importance of prenatal depression screening and preventive interventions for children of pregnant individuals with depression to support healthy development. Future research is needed to clarify whether these findings reflect overlap in genetic risk for depression and ASD-related traits or another mechanism.
(© 2023 International Society for Autism Research, Wiley Periodicals LLC.)
Databáze: MEDLINE
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