Evaluation of drug-resistant tuberculosis treatment outcome in Limpopo province, South Africa.

Autor: Seloma NM; Department of Pathology and Medical Sciences, Faculty of Health Sciences, University of Limpopo, Polokwane. sisloga@gmail.com., Makgatho ME, Maimela E
Jazyk: angličtina
Zdroj: African journal of primary health care & family medicine [Afr J Prim Health Care Fam Med] 2023 Jul 31; Vol. 15 (1), pp. e1-e7. Date of Electronic Publication: 2023 Jul 31.
DOI: 10.4102/phcfm.v15i1.3764
Abstrakt: Background: South Africa has the second-highest tuberculosis (TB) incidence globally. Drug-resistant TB (DR-TB) treatment has less successful treatment outcomes as compared with susceptible TB, and it hinders TB control and management programmes.
Aim: This study aimed to evaluate drug-resistant TB treatment outcomes and factors associated with successful treatment outcomes.
Setting: The study was conducted in five districts in Limpopo province.
Methods: The study design was retrospective and descriptive. Patients' demographic data, data on clinical characteristics and treatment outcomes data were extracted from the electronic drug-resistant tuberculosis register (EDRWeb) database system for the period, 2010-2018, in Limpopo province. Frequency, percentages and bivariate and multivariate logistic regression were used to analyse data using Statistical Package for Social Sciences version 27.0. The significance difference was determined at a 95% confidence interval and p 0.05.
Results: A total of 385 drug-resistant records were included in this study. The treatment success rate was 223 (57.9%). A total of 197 (51.2%) patients were cured, 26 (6.8%) completed treatment, 19 (4.9%) treatment failure, 62 (16.1%) died, 78 (20.6%) were recorded as the loss to follow-up, 1 (0.3%) moved to another country and 2 (0.5%) were transferred out.
Conclusion: The treatment success rate was 57.9%, which is still below targets set by National Strategic Plan in South Africa and World Health Organization End TB targets.Contribution: The findings of the study reveal that to achieve successful DR-TB control programme and attain End TB targets, monitoring of treatment outcomes is crucial.
Databáze: MEDLINE
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