Severe Acute Bacterial Infections in Children With Sickle Cell Disease in Togo.

Autor:	Gbadoé AD; Hemato-oncology Unit of the Pediatrics Department.; Pediatrics Department of the District Hospital of Be.; Faculty of Health Sciences, University of Lomé (Togo)., Guédénon KM; Hemato-oncology Unit of the Pediatrics Department.; Faculty of Health Sciences, University of Lomé (Togo)., N'zonou M; Pediatrics Department of the District Hospital of Be., Adamou M; Pediatrics Department of the District Hospital of Be., Akolly D; Hemato-oncology Unit of the Pediatrics Department.; Faculty of Health Sciences, University of Lomé (Togo)., Guédéhoussou T; Faculty of Health Sciences, University of Lomé (Togo).; Pediatrics Department of the Regional Hospital of Lomé, Lomé, Togo., Dagnra AY; Microbiology Department, Sylvanus Olympio Teaching Hospital.; Faculty of Health Sciences, University of Lomé (Togo).
Jazyk:	angličtina
Zdroj:	Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2023 Oct 01; Vol. 45 (7), pp. 404-408. Date of Electronic Publication: 2023 Jul 27.
DOI:	10.1097/MPH.0000000000002710
Abstrakt:	Background: Bacterial infections are considered a major cause of morbidity and mortality in patients, especially children, with sickle cell disease. Objectives: This study aims at determining, a year after the introduction of the 13-valent pneumococcal conjugate vaccine the distribution of severe acute bacterial infections and germs in children with sickle cell disease. Patients and Methods: Records of children 0 to 15 years of age and admitted from January 1, 2015 to December 31, 2019 (5 y), were examined retrospectively in the four sickle cell monitoring units in Lomé. Results: The main infections found were pleuropulmonary (46.1%), urinary tract (32.8%), and osteoarticular (9.3%). A germ was isolated in 139 of the 265 cases (52.4%). 65.5% of the microorganisms isolated were Gram-negative organisms, with mostly Escherichia coli (31.6%) , and Klebsiella pneumoniae (18%) being the main germs. They were mainly responsible of urinary tract and osteoarticular infections. The majority of these Enterobacteriaceae was Extended-Spectrum Beta-Lactamase-Producing (41.1%, n = 37). Gram-positive cocci were represented by Staphylococcus sp (25.9%), Streptococcus sp (4.3%), Streptococcus pneumoniae (2.9%), and Enterococcus (1.4%). Staphylococcus aureus was the most common germ in pleuropulmonary (40%), osteoarticular (47.3%), and sepsis (28.6%) infections. Conclusion: Even if the infections found remained classic, there is a redistribution of germs with a decline in Salmonella and increase of Escherichia coli , Klebsiella pneumoniae , and Staphylococcus aureus . Competing Interests: The authors declare no conflict of interest. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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