Klebsiella pneumoniae infection in cynomolgus monkeys at primate research center facility in Indonesia.

Autor: Saputro S; Primate Research Center, IPB University, Bogor, Indonesia.; Primatology Graduate Study Program, IPB University, Bogor, Indonesia., Saepuloh U; Primate Research Center, IPB University, Bogor, Indonesia.; Primatology Graduate Study Program, IPB University, Bogor, Indonesia., Darusman HS; Primate Research Center, IPB University, Bogor, Indonesia.; Primatology Graduate Study Program, IPB University, Bogor, Indonesia.; School of Veterinary Medicine and Biomedical Science, IPB University, Bogor, Indonesia., Putriyani W; Primate Research Center, IPB University, Bogor, Indonesia., Permanawati; Primate Research Center, IPB University, Bogor, Indonesia., Ayuningsih ED; Primate Research Center, IPB University, Bogor, Indonesia., Prabandari SA; Primate Research Center, IPB University, Bogor, Indonesia., Setyawati D; Primate Research Center, IPB University, Bogor, Indonesia., Pamungkas J; Primate Research Center, IPB University, Bogor, Indonesia.; Primatology Graduate Study Program, IPB University, Bogor, Indonesia.; School of Veterinary Medicine and Biomedical Science, IPB University, Bogor, Indonesia.
Jazyk: angličtina
Zdroj: Journal of medical primatology [J Med Primatol] 2023 Dec; Vol. 52 (6), pp. 361-368. Date of Electronic Publication: 2023 Jul 31.
DOI: 10.1111/jmp.12665
Abstrakt: Background: Klebsiella pneumoniae infection in nonhuman primates has been widely reported and causes significant morbidity and mortality. Animal deaths occur routinely at the Primate Research Center of IPB University. The results of necropsy and culture suggested a K. pneumoniae infection.
Methods: A mass health assessment of Cynomolgus monkeys (n = 429) was carried out by physical examination and molecular targeting K. pneumoniae (n = 96), family of Coronaviridae (n = 148) and Paramyxoviridae (n = 148).
Results: A total of 49.18% of the animals had clinical symptoms of respiratory disorders, abscesses, trauma, and others. PCR results indicated that 28.57% were positive for K. pneumoniae with 35.71% mortality, while all samples were negative for both virus families.
Conclusions: There have been outbreaks caused by K. pneumoniae and/or K. pneumoniae subsp. pneumoniae. This disease is chronic, infects all of the buildings, and no tendency for disease transmission according to gender and age class.
(© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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