Decoding the impact of nuclear organization on antigenic variation in parasites.

Autor: Barcons-Simon A; Division of Experimental Parasitology, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.; Biomedical Center, Division of Physiological Chemistry, Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany., Carrington M; Department of Biochemistry, University of Cambridge, Cambridge, UK., Siegel TN; Division of Experimental Parasitology, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany. n.siegel@lmu.de.; Biomedical Center, Division of Physiological Chemistry, Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany. n.siegel@lmu.de.
Jazyk: angličtina
Zdroj: Nature microbiology [Nat Microbiol] 2023 Aug; Vol. 8 (8), pp. 1408-1418. Date of Electronic Publication: 2023 Jul 31.
DOI: 10.1038/s41564-023-01424-9
Abstrakt: Antigenic variation as a strategy to evade the host adaptive immune response has evolved in divergent pathogens. Antigenic variation involves restricted, and often mutually exclusive, expression of dominant antigens and a periodic switch in antigen expression during infection. In eukaryotes, nuclear compartmentalization, including three-dimensional folding of the genome and physical separation of proteins in compartments or condensates, regulates mutually exclusive gene expression and chromosomal translocations. In this Review, we discuss the impact of nuclear organization on antigenic variation in the protozoan pathogens Trypanosoma brucei and Plasmodium falciparum. In particular, we highlight the relevance of nuclear organization in both mutually exclusive antigen expression and genome stability, which underlie antigenic variation.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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