Revaccination for Hepatitis B in Previous Nonresponders Following Hepatitis C Eradication.

Autor:	Powell JG; Department of Gastroenterology and Hepatology, Hennepin Healthcare, Minneapolis, Minnesota, USA., Goble SR; Department of Medicine, Hennepin Healthcare, Minneapolis, Minnesota, USA., Debes JD; Department of Gastroenterology and Hepatology, Hennepin Healthcare, Minneapolis, Minnesota, USA.; Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2024 Feb 14; Vol. 229 (2), pp. 341-345.
DOI:	10.1093/infdis/jiad301
Abstrakt:	Background: Patients with chronic hepatitis C virus (HCV) do not respond to hepatitis B virus (HBV) vaccination as efficiently as the general population. We assessed if revaccination after HCV treatment resulted in improved response. Methods: Previous HBV vaccine nonresponders were prospectively recruited for revaccination after HCV eradication. Hepatitis B surface antibody (HBsAb) testing was performed 1 month after series completion. Results: Follow-up HBsAb testing was performed in 31 of 34 enrolled patients with 21 (67.7%) reactive results. There were no significant differences in HBsAb reactivity based on age, sex, race, or advanced fibrosis presence. Conclusions: HBV vaccine nonresponders should be considered for revaccination following HCV cure. Competing Interests: Potential conflict of interest . All authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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