Indoor Pollution and Lung Function Decline in Current and Former Smokers: SPIROMICS AIR.

Autor: Hansel NN; Division of Pulmonary and Critical Care Medicine and.; Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland., Woo H; Division of Pulmonary and Critical Care Medicine and., Koehler K; Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland., Gassett A; Department of Environmental and Occupational Health Sciences and., Paulin LM; Section of Pulmonary and Critical Care, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine, Hanover, New Hampshire., Alexis NE; Center for Environmental Medicine, Asthma and Lung Biology, Division of Allergy and Immunology, University of North Carolina, Chapel Hill, North Carolina., Putcha N; Division of Pulmonary and Critical Care Medicine and., Lorizio W; Division of Pulmonary and Critical Care Medicine and., Fawzy A; Division of Pulmonary and Critical Care Medicine and., Belz D; Division of Pulmonary and Critical Care Medicine and., Sack C; Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, Washington., Barr RG; Division of Pulmonary and Critical Care, Presbyterian Hospital, Columbia University Medical Center, New York, New York., Martinez FJ; Department of Internal Medicine, Weill Cornell Medical College, New York, New York., Han MK; Division of Pulmonary and Critical Care, University of Michigan Health System, Ann Arbor, Michigan., Woodruff P; Division of Pulmonary and Critical Care Medicine, Department of Medicine, and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California., Pirozzi C; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, Utah., Paine R 3rd; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, Utah., Barjaktarevic I; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, Los Angeles, Los Angeles, California; and., Cooper CB; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, Los Angeles, Los Angeles, California; and., Ortega V; Pulmonary, Critical Care, Allergy, and Immunologic Medicine, Department of Internal Medicine, Wake Forest University, Winston-Salem, North Carolina., Zusman M; Department of Environmental and Occupational Health Sciences and., Kaufman JD; Department of Environmental and Occupational Health Sciences and.
Jazyk: angličtina
Zdroj: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2023 Nov 15; Vol. 208 (10), pp. 1042-1051.
DOI: 10.1164/rccm.202302-0207OC
Abstrakt: Rationale: Indoor pollutants have been associated with chronic obstructive pulmonary disease morbidity, but it is unclear whether they contribute to disease progression. Objectives: We aimed to determine whether indoor particulate matter (PM) and nitrogen dioxide (NO 2 ) are associated with lung function decline among current and former smokers. Methods: Of the 2,382 subjects with a history of smoking in SPIROMICS AIR, 1,208 participants had complete information to estimate indoor PM and NO 2 , using individual-based prediction models, in relation to measured spirometry at two or more clinic visits. We used a three-way interaction model between time, pollutant, and smoking status and assessed the indoor pollutant-associated difference in FEV 1 decline separately using a generalized linear mixed model. Measurements and Main Results: Participants had an average rate of FEV 1 decline of 60.3 ml/yr for those currently smoking compared with 35.2 ml/yr for those who quit. The association of indoor PM with FEV 1 decline differed by smoking status. Among former smokers, every 10 μg/m 3 increase in estimated indoor PM was associated with an additional 10 ml/yr decline in FEV 1 ( P  = 0.044). Among current smokers, FEV 1 decline did not differ by indoor PM. The results of indoor NO 2 suggest trends similar to those for PM ⩽2.5 μm in aerodynamic diameter. Conclusions: Former smokers with chronic obstructive pulmonary disease who live in homes with high estimated PM have accelerated lung function loss, and those in homes with low PM have lung function loss similar to normal aging. In-home PM exposure may contribute to variability in lung function decline in people who quit smoking and may be a modifiable exposure.
Databáze: MEDLINE