(Bio)Functionalisation of Metal-Organic Polyhedra by Using Click Chemistry.

Autor: Hernández-López L; Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technology, Campus UAB, Bellaterra, 08193, Barcelona, Spain.; Departament de Química, Facultat de Ciencies, Universitat Autonoma de Barcelona, 08193, Bellaterra, Spain., von Baeckmann C; Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technology, Campus UAB, Bellaterra, 08193, Barcelona, Spain.; Departament de Química, Facultat de Ciencies, Universitat Autonoma de Barcelona, 08193, Bellaterra, Spain., Martínez-Esaín J; Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technology, Campus UAB, Bellaterra, 08193, Barcelona, Spain., Cortés-Martínez A; Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technology, Campus UAB, Bellaterra, 08193, Barcelona, Spain.; Departament de Química, Facultat de Ciencies, Universitat Autonoma de Barcelona, 08193, Bellaterra, Spain., Faraudo J; Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), 08193, Bellaterra, Spain., Caules C; Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technology, Campus UAB, Bellaterra, 08193, Barcelona, Spain.; Departament de Química, Facultat de Ciencies, Universitat Autonoma de Barcelona, 08193, Bellaterra, Spain., Parella T; Servei de Ressonància Magnètica Nuclear, Universitat Autònoma de Barcelona, Campus UAB, Bellaterra, 08193, Barcelona, Spain., Maspoch D; Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technology, Campus UAB, Bellaterra, 08193, Barcelona, Spain.; Departament de Química, Facultat de Ciencies, Universitat Autonoma de Barcelona, 08193, Bellaterra, Spain.; ICREA, Pg. Lluís Companys 23, 08010, Barcelona, Spain., Carné-Sánchez A; Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technology, Campus UAB, Bellaterra, 08193, Barcelona, Spain.; Departament de Química, Facultat de Ciencies, Universitat Autonoma de Barcelona, 08193, Bellaterra, Spain.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2023 Oct 26; Vol. 29 (60), pp. e202301945. Date of Electronic Publication: 2023 Sep 19.
DOI: 10.1002/chem.202301945
Abstrakt: The surface chemistry of Metal-Organic Polyhedra (MOPs) is crucial to their physicochemical properties because it governs how they interact with external substances such as solvents, synthetic organic molecules, metal ions, and even biomolecules. Consequently, the advancement of synthetic methods that facilitate the incorporation of diverse functional groups onto MOP surfaces will significantly broaden the range of properties and potential applications for MOPs. This study describes the use of copper(I)-catalysed, azide-alkyne cycloaddition (CuAAC) click reactions to post-synthetically modify the surface of alkyne-functionalised cuboctahedral MOPs. To this end, a novel Rh(II)-based MOP with 24 available surface alkyne groups was synthesised. Each of the 24 alkyne groups on the surface of the "clickable" Rh-MOP can react with azide-containing molecules at room temperature, without compromising the integrity of the MOP. The wide substrate catalogue and orthogonal nature of CuAAC click chemistry was exploited to densely functionalise MOPs with diverse functional groups, including polymers, carboxylic and phosphonic acids, and even biotin moieties, which retained their recognition capabilities once anchored onto the surface of the MOP.
(© 2023 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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