| Autor: |
Karavallil Achuthan S; Department of Psychology & The Center for Innovative Research in Autism, University of Alabama, Tuscaloosa, Alabama, USA., Stavrinos D; Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Holm HB; Children's Hospital of Atlanta, Atlanta, Georgia, USA., Anteraper SA; Stephens Family Clinical Research Institute, Carle Illinois Advanced Imaging Center, Urbana, Illinois, USA., Kana RK; Department of Psychology & The Center for Innovative Research in Autism, University of Alabama, Tuscaloosa, Alabama, USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Brain connectivity [Brain Connect] 2023 Nov; Vol. 13 (9), pp. 528-540. Date of Electronic Publication: 2023 Aug 22. |
| DOI: |
10.1089/brain.2023.0006 |
| Abstrakt: |
Background: Autism and attention-deficit/hyperactivity disorder (ADHD) are comorbid neurodevelopmental disorders that share common and distinct neurobiological mechanisms, with disrupted brain connectivity patterns being a hallmark feature of both conditions. It is challenging to gain a mechanistic understanding of the underlying disorder, because brain connectivity changes in autism and ADHD are heterogeneous. Objectives: The present resting state functional MRI (rs-fMRI) study focuses on investigating the shared and distinct resting state-fMRI connectivity (rsFC) patterns in autistic and ADHD adults using multi-voxel pattern analysis (MVPA). By identifying spatial patterns of fMRI activity across a given time course, MVPA is an innovative and powerful method for generating seed regions of interest (ROIs) without a priori hypotheses. Methods: We performed a data-driven, whole-brain, connectome-wide MVPA on rs-fMRI data collected from 15 autistic, 19 ADHD, and 15 neurotypical (NT) young adults. Results: MVPA identified cerebellar vermis 9, precuneus, and the right cerebellum VI for autistic versus NT, right inferior frontal gyrus and vermis 9 for ADHD versus NT, and right dorsolateral prefrontal cortex for autistic versus ADHD as significant clusters. Post hoc seed-to-voxel analyses using these clusters as seed ROIs were performed for further characterization of group differences. The cerebellum VI, vermis, and precuneus in autistic adults, and the vermis and frontal regions in ADHD showed different connectivity patterns in comparison with NT. Conclusions: The study characterizes the rsFC profile of cerebellum with key cortical areas in autism and ADHD, and it emphasizes the importance of studying the role of the functional connectivity of the cerebellum in neurodevelopmental disorders. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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