The Effects of Subthalamic Nucleus Deep Brain Stimulation and Retention Delay on Memory-Guided Reaching Performance in People with Parkinson's Disease.

Autor: Trevarrow MP; Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA., Munoz MJ; Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA., Rivera YM; Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA., Arora R; Morsani College of Medicine, University of South Florida, Tampa, FL, USA., Drane QH; Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA., Rosenow JM; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Sani SB; Department of Neurosurgery, Rush University Medical Center, Chicago, IL, USA., Pal GD; Department of Neurology, Division of Movement Disorders, Rutgers - Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Verhagen Metman L; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Goelz LC; Department of Kinesiology and Nutrition, UIC College of Applied Health Sciences, Chicago, IL, USA., Corcos DM; Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA.; McCormick School of Engineering, Northwestern University, Evanston, IL, USA., David FJ; Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA.
Jazyk: angličtina
Zdroj: Journal of Parkinson's disease [J Parkinsons Dis] 2023; Vol. 13 (6), pp. 917-935.
DOI: 10.3233/JPD-225041
Abstrakt: Background: Subthalamic nucleus deep brain stimulation (STN-DBS) improves intensive aspects of movement (velocity) in people with Parkinson's disease (PD) but impairs the more cognitively demanding coordinative aspects of movement (error). We extended these findings by evaluating STN-DBS induced changes in intensive and coordinative aspects of movement during a memory-guided reaching task with varying retention delays.
Objective: We evaluated the effect of STN-DBS on motor control during a memory-guided reaching task with short and long retention delays in participants with PD and compared performance to healthy controls (HC).
Methods: Eleven participants with PD completed the motor section of the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS III) and performed a memory-guided reaching task under four different STN-DBS conditions (DBS-OFF, DBS-RIGHT, DBS-LEFT, and DBS-BOTH) and two retention delays (0.5 s and 5 s). An additional 13 HC completed the memory-guided reaching task.
Results: Unilateral and bilateral STN-DBS improved the MDS-UPDRS III scores. In the memory-guided reaching task, both unilateral and bilateral STN-DBS increased the intensive aspects of movement (amplitude and velocity) in the direction toward HC but impaired coordinative aspects of movement (error) away from the HC. Furthermore, movement time was decreased but reaction time was unaffected by STN-DBS. Shorter retention delays increased amplitude and velocity, decreased movement times, and decreased error, but increased reaction times in the participants with PD. There were no interactions between STN-DBS condition and retention delay.
Conclusion: STN-DBS may affect cognitive-motor functioning by altering activity throughout cortico-basal ganglia networks and the oscillatory activity subserving them.
Databáze: MEDLINE
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