Role of endoplasmic reticulum stress-related unfolded protein response and its implications in dengue virus infection for biomarker development.

Autor: Das B; School of Biotechnology, Kalinga Institute of Industrial Technology, KIIT Deemed to Be University, Bhubaneswar, Odisha 751024, India. Electronic address: biswadeep.das@kiitbiotech.ac.in., Samal S; School of Biotechnology, Kalinga Institute of Industrial Technology, KIIT Deemed to Be University, Bhubaneswar, Odisha 751024, India., Hamdi H; Zoology Department, Faculty of Science, Cairo University, Giza 12613, Egypt; Department of Biology, College of Science, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia., Pal A; School of Biotechnology, Kalinga Institute of Industrial Technology, KIIT Deemed to Be University, Bhubaneswar, Odisha 751024, India., Biswas A; School of Biotechnology, Kalinga Institute of Industrial Technology, KIIT Deemed to Be University, Bhubaneswar, Odisha 751024, India., Behera J; School of Biotechnology, Kalinga Institute of Industrial Technology, KIIT Deemed to Be University, Bhubaneswar, Odisha 751024, India., Singh G; Department of Anatomy, Kalinga Institute of Medical Sciences, KIIT-DU, Bhubaneswar, Odisha 751024, India., Behera CK; Department of Pediatrics, Kalinga Institute of Medical Sciences, KIIT-DU, Bhubaneswar, Odisha 751024, India., Sahoo DP; School of Biotechnology, Kalinga Institute of Industrial Technology, KIIT Deemed to Be University, Bhubaneswar, Odisha 751024, India., Pati S; Regional Medical Research Centre-ICMR, Nalco Square, Bhubaneswar, Odisha 751023, India.
Jazyk: angličtina
Zdroj: Life sciences [Life Sci] 2023 Sep 15; Vol. 329, pp. 121982. Date of Electronic Publication: 2023 Jul 28.
DOI: 10.1016/j.lfs.2023.121982
Abstrakt: Dengue virus (DENV) causes debilitating disease in humans, which varies at different rates in host cells, such as monocytes, macrophages, dendritic cells, Langerhans cells, and other cell types. Such heterogeneity in DENV infection in cells could be attributed to a range of factors, including host cell immune response, anti-viral cellular proteins, and virus mediated cellular autophagy. This review delineates an important feature of every cell, the unfolded protein response (UPR) that is attributed to the accumulation of several viral and unfolded/misfolded proteins, such as in DENV infection. UPR is a normal process to counteract endoplasmic reticulum (ER) stress that leads to cell autophagy; though the phenomenon is markedly upregulated during DENV infection. This could be attributed to the uncontrolled activation of the key UPR signaling pathways: inositol-requiring transmembrane kinase/endoribonuclease 1 (IRE1), protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), and activating transcription factor-6 (ATF6), which promote cell autophagy under normal and diseased conditions through the downstream regulation of apoptosis promoting factors such as X-box binding protein (XBP1), GADD34, and ATF-6. Because DENV can modulate these signaling cascades, by promoting dysregulated cell autophagy, the ER stress mediated UPR pathways and the inherent agents could play an important role in delineating the severity of dengue infection with a potential for developing DENV targeted therapeutics.
Competing Interests: Declaration of competing interest None.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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