The food additive titanium dioxide hinders intestinal production of TGF-β and IL-10 in mice, and long-term exposure in adults or from perinatal life blocks oral tolerance to ovalbumin.

Autor: Lamas B; Toxalim UMR1331 (Research Centre in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France. Electronic address: bruno.lamas@inrae.fr., Chevalier L; Group Physic of Materials, GPM-UMR6634, CNRS, Rouen University, Rouen, France., Gaultier E; Toxalim UMR1331 (Research Centre in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France., Cartier C; Toxalim UMR1331 (Research Centre in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France., Weingarten L; Centre de MicroCaractérisation Raimond Castaing, UAR 3623, Toulouse, France., Blanc X; Sciences de l'Animal et de l'Aliment de Jouy, SAAJ UE1298, INRAE, Jouy-en-Josas, France., Fisicaro P; Department for Biomedical and Inorganic Chemistry, LNE, Paris, France., Oster C; Department for Biomedical and Inorganic Chemistry, LNE, Paris, France., Noireaux J; Department for Biomedical and Inorganic Chemistry, LNE, Paris, France., Evariste L; Toxalim UMR1331 (Research Centre in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France., Breyner NM; Toxalim UMR1331 (Research Centre in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France., Houdeau E; Toxalim UMR1331 (Research Centre in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France. Electronic address: eric.houdeau@inrae.fr.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2023 Sep; Vol. 179, pp. 113974. Date of Electronic Publication: 2023 Jul 28.
DOI: 10.1016/j.fct.2023.113974
Abstrakt: Food hypersensitivities are increasing in industrialized countries, and foodborne nanoparticles (NPs) are suspected as co-factors in their aetiology. Food-grade titanium dioxide (fg-TiO 2 ), a food colouring agent, is composed of NPs with immunomodulatory properties. We investigated whether fg-TiO 2 may compromise the establishment of oral tolerance (OT) to food proteins using a model of OT induction to ovalbumin (OVA) in mice, and whether a perinatal exposure could trigger this effect. In pregnant mice fed a TiO 2 -enriched diet, ICP-MS and TEM-EDX analyses showed passage of TiO 2 NPs into the foetus. When their weaned offspring were fed the same diet, a breakdown in OT to OVA was observed at adulthood, characterized by a high anti-OVA IgG production compared to controls. However, adult mice directly exposed to fg-TiO 2 did not induce OT to OVA either, ruling out a developmental origin for these effects. When these mice were orally challenged with OVA, intestinal inflammation demonstrated hypersensitivity to OVA. In OVA-naïve mice, fg-TiO 2 exposure impaired intestinal TGF-β and IL-10 production, of key role in OT induction and maintenance. These findings showed that long-term exposure to TiO 2 as food additive alters anti-inflammatory cytokine profile, and leads to OT failure regardless of the timing of TiO 2 exposure throughout life.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier Ltd.)
Databáze: MEDLINE
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