Play and tickling responses map to the lateral columns of the rat periaqueductal gray.

Autor:	Gloveli N; Bernstein Center for Computational Neuroscience Berlin, Humboldt-Universität zu Berlin, Philippstr. 13, Haus 6, 10115 Berlin, Germany; Charité-Universitätsmedizin Berlin, Einstein Center for Neurosciences, Berlin, 10117 Berlin, Germany., Simonnet J; Bernstein Center for Computational Neuroscience Berlin, Humboldt-Universität zu Berlin, Philippstr. 13, Haus 6, 10115 Berlin, Germany., Tang W; Bernstein Center for Computational Neuroscience Berlin, Humboldt-Universität zu Berlin, Philippstr. 13, Haus 6, 10115 Berlin, Germany., Concha-Miranda M; Bernstein Center for Computational Neuroscience Berlin, Humboldt-Universität zu Berlin, Philippstr. 13, Haus 6, 10115 Berlin, Germany., Maier E; Bernstein Center for Computational Neuroscience Berlin, Humboldt-Universität zu Berlin, Philippstr. 13, Haus 6, 10115 Berlin, Germany; Department of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Dvorzhak A; Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Neuroscience Research Center, 10117 Berlin, Germany., Schmitz D; Bernstein Center for Computational Neuroscience Berlin, Humboldt-Universität zu Berlin, Philippstr. 13, Haus 6, 10115 Berlin, Germany; NeuroCure Cluster of Excellence, Humboldt-Universität zu Berlin, Berlin, Germany; Charité-Universitätsmedizin Berlin, Einstein Center for Neurosciences, Berlin, 10117 Berlin, Germany; Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Neuroscience Research Center, 10117 Berlin, Germany; German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany., Brecht M; Bernstein Center for Computational Neuroscience Berlin, Humboldt-Universität zu Berlin, Philippstr. 13, Haus 6, 10115 Berlin, Germany; NeuroCure Cluster of Excellence, Humboldt-Universität zu Berlin, Berlin, Germany; Charité-Universitätsmedizin Berlin, Einstein Center for Neurosciences, Berlin, 10117 Berlin, Germany. Electronic address: michael.brecht@bccn-berlin.de.
Jazyk:	angličtina
Zdroj:	Neuron [Neuron] 2023 Oct 04; Vol. 111 (19), pp. 3041-3052.e7. Date of Electronic Publication: 2023 Jul 28.
DOI:	10.1016/j.neuron.2023.06.018
Abstrakt:	The persistence of play after decortication points to a subcortical mechanism of play control. We found that global blockade of the rat periaqueductal gray with either muscimol or lidocaine interfered with ticklishness and play. We recorded vocalizations and neural activity from the periaqueductal gray of young, playful rats during interspecific touch, play, and tickling. Rats vocalized weakly to touch and more strongly to play and tickling. Periaqueductal gray units showed diverse but strong modulation to tickling and play. Hierarchical clustering based on neuronal responses to play and tickling revealed functional clusters mapping to different periaqueductal gray columns. Specifically, we observed play-neutral/tickling-inhibited and tickling/play-neutral units in dorsolateral and dorsomedial periaqueductal gray columns. In contrast, strongly play/tickling-excited units mapped to the lateral columns and were suppressed by anxiogenic conditions. Optogenetic inactivation of lateral periaqueductal columns disrupted ticklishness and play. We conclude that the lateral periaqueductal gray columns are decisive for play and laughter. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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