Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis.

Autor: Jia W; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. weijia1@hkbu.edu.hk., Li Y; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China., Cheung KCP; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China., Zheng X; Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China. joyzheng99@sjtu.edu.cn.
Jazyk: angličtina
Zdroj: Science China. Life sciences [Sci China Life Sci] 2024 May; Vol. 67 (5), pp. 865-878. Date of Electronic Publication: 2023 Jul 27.
DOI: 10.1007/s11427-023-2353-0
Abstrakt: Bile acids (BAs) play a crucial role in nutrient absorption and act as key regulators of lipid and glucose metabolism and immune homeostasis. Through the enterohepatic circulation, BAs are synthesized, metabolized, and reabsorbed, with a portion entering the vascular circulation and distributing systemically. This allows BAs to interact with receptors in all major organs, leading to organ-organ interactions that regulate both local and global metabolic processes, as well as the immune system. This review focuses on the whole-body effects of BA-mediated metabolic and immunological regulation, including in the brain, heart, liver, intestine, eyes, skin, adipose tissue, and muscle. Targeting BA synthesis and receptor signaling is a promising strategy for the development of novel therapies for various diseases throughout the body.
(© 2023. Science China Press.)
Databáze: MEDLINE
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