Differential effects of aging on hippocampal ultrastructure in male vs. female rats.

Autor: Zhvania M; School of Natural Sciences and Medicine, Ilia State University, 3/5 K. Cholokashvili Avenue, 0162, Tbilisi, Georgia. mzia_zhvania@iliauni.edu.ge.; Department of Brain Ultrastructure and Nanoarchitecture, Ivane Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia. mzia_zhvania@iliauni.edu.ge., Japaridze N; Department of Brain Ultrastructure and Nanoarchitecture, Ivane Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia.; New Vision University, Tbilisi, Georgia., Tizabi Y; Department of Pharmacology, Howard University College of Medicine, Washington, DC, USA., Lomidze N; School of Natural Sciences and Medicine, Ilia State University, 3/5 K. Cholokashvili Avenue, 0162, Tbilisi, Georgia.; Department of Brain Ultrastructure and Nanoarchitecture, Ivane Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia., Pochkhidze N; School of Natural Sciences and Medicine, Ilia State University, 3/5 K. Cholokashvili Avenue, 0162, Tbilisi, Georgia.; Department of Brain Ultrastructure and Nanoarchitecture, Ivane Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia., Rzayev F; Department of Histology, Embryology and Cytology, Azerbaijan Medical University, Baku, Azerbaijan., Gasimov E; Department of Histology, Embryology and Cytology, Azerbaijan Medical University, Baku, Azerbaijan.
Jazyk: angličtina
Zdroj: Biogerontology [Biogerontology] 2023 Dec; Vol. 24 (6), pp. 925-935. Date of Electronic Publication: 2023 Jul 29.
DOI: 10.1007/s10522-023-10052-z
Abstrakt: Age-related decline in physical and cognitive functions are facts of life that do not affect everyone to the same extent. We had reported earlier that such cognitive decline is both sex- and context-dependent. Moreover, age-associated ultrastructural changes were observed in the hippocampus of male rats. In this study, we sought to determine potential differences in ultrastructural changes between male and female rats at various stages of life. We performed quantitative electron microscopic evaluation of hippocampal CA1 region, an area intimately involved in cognitive behavior, in both male and female adolescent, adult and old Wistar rats. Specifically, we measured the number of docking synaptic vesicles in axo-dendritic synapses, the length of active zone as well as the total number of synaptic vesicles. Distinct age- and sex-dependent effects were observed in several parameters. Thus, adult female rats had the lowest synaptic active zone compared to both adolescent and old female rats. Moreover, the same parameter was significantly lower in adult and old female rats compared to their male counterparts. On the other hand, old male rats had significantly lower number of total synaptic vesicles compared to both adolescent and adult male rats as well as compared to their female counterparts. Taken together, it may be suggested that age- and sex-dependent ultrastructural changes in the hippocampus may underlie at least some of the differences in cognitive functions among these groups.
(© 2023. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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