| Autor: |
Oliynyk OV; Department of Anaesthesiology and Intensive Care, Bogomolets National Medical University, 01601 Kyiv, Ukraine.; Department of Emergency Medicine, Rzeszow University, 35-310 Rzeszow, Poland., Rorat M; Department of Forensic Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland., Solyarik SO; Department of Anesthesiology and Intensive Care, Kyiv City Clinical Hospital No 4, 01030 Kyiv, Ukraine., Lukianchuk VA; Department of Anesthesiology and Intensive Care, Kyiv City Clinical Hospital No 4, 01030 Kyiv, Ukraine., Dubrov SO; Department of Anaesthesiology and Intensive Care, Bogomolets National Medical University, 01601 Kyiv, Ukraine., Guryanov VH; Department of Medical Statistics, Bogomolets National Medical University, 01601 Kyiv, Ukraine., Oliynyk YV; Department of Civilization Diseases, University of Information Technology and Management in Rzeszow, 35-310 Rzeszow, Poland., Yaroslavskaya SM; Department of Anesthesiology and Intensive Care, Kyiv City Clinical Hospital No 4, 01030 Kyiv, Ukraine., Szalast R; Department of Internal Medicine, Pneumonology and Allergology, Wroclaw Medical University, 50-367 Wroclaw, Poland., Barg W; Department of Human Physiology, Rzeszow University, 35-310 Rzeszow, Poland. |
| Abstrakt: |
COVID-19 is an independent risk factor for pulmonary embolism (PE). Little is known about alteplase therapy in this patient group. A retrospective study analyzed 74 patients with PE and acute respiratory distress syndrome (ARDS) due to COVID-19 who were hospitalized in the intensive care unit in 2021. Patients with or without confirmed right heart thrombi (RHT) were treated with unfractionated heparin or alteplase. The mortality rate in patients with RHT treated with heparin was 100% compared to 37.9% and 55.2% in those treated with alteplase without RHT and alteplase with RHT, respectively. The risk of death in the alteplase group increased with delayed thrombolysis ( p = 0.009, odds ratio (OR) = 1.73 95% CI (confidence interval) 1.14-2.62), increased D-dimer concentration ( p = 0.02, OR = 1.43 95% CI 1.06-1.93), and decreased PaO 2 /FiO 2 ratio ( p = 0.001, OR = 0.56 95% CI 0.41-0.78). The receiver operating characteristic method determined that a 1-day delay in thrombolytic treatment, D-dimer concentration >5.844 mg/L, and PaO 2 /FiO 2 <144 mmHg predicted a fatal outcome. The risk of death in patients with severe COVID-19 with ARDS and PE increases with higher D-dimer levels, decreased PaO 2 /FiO 2 , and delayed thrombolytic treatment. Thrombolysis seems to be treatment of choice in severe COVID-19 with PE and RHT. It should be carried out as soon as possible after the diagnosis is established. |
